Heterogeneity in Metabolic Responses to Dietary Fructose.
added sugars
complex diseases
genetic variants
individual variability
metabolic response
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
11
2018
accepted:
05
09
2019
entrez:
19
11
2019
pubmed:
19
11
2019
medline:
19
11
2019
Statut:
epublish
Résumé
Consumption of fructose has dramatically increased in past few decades in children and adults. Increasing evidence indicates that added sugars (particularly fructose) have adverse effects on metabolism and lead to numerous cardiometabolic diseases. Although both fructose and glucose are components of sucrose and high fructose corn syrup, the sugars have different metabolic fates in the human body and the effects of fructose on health are thought to be more adverse than glucose. Studies have also shown that the metabolic effects of fructose differ between individuals based on their genetic background, as individuals with specific SNPs and risk alleles seem to be more susceptible to the adverse metabolic effects of fructose. The current review discusses the metabolic effects of fructose on key complex diseases and discusses the heterogeneity in metabolic responses to dietary fructose in humans.
Identifiants
pubmed: 31737029
doi: 10.3389/fgene.2019.00945
pmc: PMC6834945
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
945Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK056350
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Informations de copyright
Copyright © 2019 Hou, Panda and Voruganti.
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