Age-dependent clinical and echocardiographic manifestations of aortic stenosis in an unselected, non-biased cohort.
Aortic stenosis (AS)
acquired valve disease
echocardiography
Journal
Cardiovascular diagnosis and therapy
ISSN: 2223-3652
Titre abrégé: Cardiovasc Diagn Ther
Pays: China
ID NLM: 101601613
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
entrez:
19
11
2019
pubmed:
19
11
2019
medline:
19
11
2019
Statut:
ppublish
Résumé
Age, clinical presentation and echocardiographic parameters are important factors in the decision on an individualized therapeutic strategy for patients with aortic stenosis (AS). Less is known about this information in a non-selected non-biased cohort. We performed a retrospective, systematic analysis of patients admitted to our hospital from 1/1/2014 to 1/6/2018 with the diagnosis of AS. We collected demographic, clinical and echocardiographic parameters. All patients were evaluated and treated in one single institution by experienced cardiologists. We classified patients into 4 age groups to compare the above-mentioned variables. Category A: patients younger than 65 years, category B age between 65-74, category C age between 75-84, and category D patients older 85. We included 321 adults with AS in our study. There was a significant correlation between the aortic valve area, aortic velocity (Vmax), aortic pressure gradients (PMax) and age. The AVA decreased, Vmax and PMax increased with age (P=0.001, P=0.042 and P=0.017, respectively). 74.1% of all patients were symptomatic, but there were no differences between the age categories (P=0.406). The incidence of cardiovascular comorbidities was high throughout all age categories. Forty-four point five percent of all patients had a coronary artery disease, but there were no differences between the age categories (P=0.221). Echocardiographic aspect of AS was similar in all age groups except the right ventricular pressure (RVP): RVP was significantly higher in patients younger than 65 years. Based on our results, we conclude that age is a weak parameter for making decisions about the optimal AS therapy. AVAs in AS decreases moderately with age. Age does not impact any clinical or echocardiographic parameters. Cardiovascular diseases and symptomatic AS are found in all age categories.
Sections du résumé
BACKGROUND
BACKGROUND
Age, clinical presentation and echocardiographic parameters are important factors in the decision on an individualized therapeutic strategy for patients with aortic stenosis (AS). Less is known about this information in a non-selected non-biased cohort.
METHODS
METHODS
We performed a retrospective, systematic analysis of patients admitted to our hospital from 1/1/2014 to 1/6/2018 with the diagnosis of AS. We collected demographic, clinical and echocardiographic parameters. All patients were evaluated and treated in one single institution by experienced cardiologists. We classified patients into 4 age groups to compare the above-mentioned variables. Category A: patients younger than 65 years, category B age between 65-74, category C age between 75-84, and category D patients older 85.
RESULTS
RESULTS
We included 321 adults with AS in our study. There was a significant correlation between the aortic valve area, aortic velocity (Vmax), aortic pressure gradients (PMax) and age. The AVA decreased, Vmax and PMax increased with age (P=0.001, P=0.042 and P=0.017, respectively). 74.1% of all patients were symptomatic, but there were no differences between the age categories (P=0.406). The incidence of cardiovascular comorbidities was high throughout all age categories. Forty-four point five percent of all patients had a coronary artery disease, but there were no differences between the age categories (P=0.221). Echocardiographic aspect of AS was similar in all age groups except the right ventricular pressure (RVP): RVP was significantly higher in patients younger than 65 years.
CONCLUSIONS
CONCLUSIONS
Based on our results, we conclude that age is a weak parameter for making decisions about the optimal AS therapy. AVAs in AS decreases moderately with age. Age does not impact any clinical or echocardiographic parameters. Cardiovascular diseases and symptomatic AS are found in all age categories.
Identifiants
pubmed: 31737532
doi: 10.21037/cdt.2019.09.13
pii: cdt-09-S2-S238
pmc: PMC6837935
doi:
Types de publication
Journal Article
Langues
eng
Pagination
S238-S246Informations de copyright
2019 Cardiovascular Diagnosis and Therapy. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors have no conflicts of interest to declare.
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