Site-Specific Conjugation for Fully Controlled Glycoconjugate Vaccine Preparation.
chemoselective ligation
cysteine mutagenesis
glycoconjugate vaccine
pneumococcal vaccine
protein conjugation
thio/maleimide ligation
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
07
2019
accepted:
10
10
2019
entrez:
19
11
2019
pubmed:
19
11
2019
medline:
19
11
2019
Statut:
epublish
Résumé
Glycoconjugate vaccines are formed by covalently link a carbohydrate antigen to a carrier protein whose role is to achieve a long lasting immune response directed against the carbohydrate antigen. The nature of the sugar antigen, its length, its ratio per carrier protein and the conjugation chemistry impact on both structure and the immune response of a glycoconjugate vaccine. In addition it has long been assumed that the sites at which the carbohydrate antigen is attached can also have an impact. These important issue can now be addressed owing to the development of novel chemoselective ligation reactions as well as techniques such as site-selective mutagenesis, glycoengineering, or extension of the genetic code. The preparation and characterization of homogeneous bivalent pneumococcal vaccines is reported. The preparation and characterization of homogeneous bivalent pneumococcal vaccines is reported. A synthetic tetrasaccharide representative of the serotype 14 capsular polysaccharide of
Identifiants
pubmed: 31737603
doi: 10.3389/fchem.2019.00726
pmc: PMC6839274
doi:
Types de publication
Journal Article
Langues
eng
Pagination
726Informations de copyright
Copyright © 2019 Pillot, Defontaine, Fateh, Lambert, Prasanna, Fanuel, Pipelier, Csaba, Violo, Camberlein and Grandjean.
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