Sodium Selenite Accentuates the Therapeutic Effect of Adriamycin Prodrug (PADM) against Gastric Cancer.
Antineoplastic Combined Chemotherapy Protocols
/ pharmacology
Apoptosis
/ drug effects
Cell Line, Tumor
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Combined Modality Therapy
Doxorubicin
/ pharmacology
Humans
Mitochondria
/ drug effects
Prodrugs
/ pharmacology
Sodium Selenite
/ pharmacology
Stomach Neoplasms
/ drug therapy
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
05
2019
revised:
09
09
2019
accepted:
11
09
2019
entrez:
19
11
2019
pubmed:
19
11
2019
medline:
4
4
2020
Statut:
epublish
Résumé
Selenium has remained a controversial character in cancer research. While its antitumor effects have been widely demonstrated, further evidence is required to establish it as a robust treatment regime. Sodium selenite (SS), an inorganic selenium, reportedly affected the proliferation and redifferentiation of gastric cancer cells, but whether it could act as a complement to conventional chemotherapeutic drugs for combination therapy is uncertain. Herein, SGC-7901 and MGC-803 gastric cancer cells were treated with PADM (Ac-Phe-Lys-PABC-ADM), a prodrug of doxorubicin/adriamycin (ADM), and the combined antitumor effects of the two drugs were evaluated. Characterization after treatment revealed that although PADM exhibited antitumor effects individually by inhibiting the proliferation and migration of gastric cancer cells and inducing apoptosis, the addition of SS significantly amplified these effects. Furthermore, gastric cancer cell apoptosis triggered by the combined treatment of SS and PADM may involve the participation of mitochondrial apoptosis, as evidenced by the changes in mitochondrial morphology and occurrence of mitochondrial fission. Collectively, SS could be a strong complementary drug that accentuates the therapeutic potential of PADM in gastric cancer treatment and management, and its significance could contribute to unique and innovative anticancer strategies.
Identifiants
pubmed: 31737654
doi: 10.1155/2019/2035682
pmc: PMC6815643
doi:
Substances chimiques
Prodrugs
0
Doxorubicin
80168379AG
Sodium Selenite
HIW548RQ3W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2035682Informations de copyright
Copyright © 2019 Shengquan Tan et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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