Loneliness in monkeys: Neuroimmune mechanisms.
Journal
Current opinion in behavioral sciences
ISSN: 2352-1546
Titre abrégé: Curr Opin Behav Sci
Pays: Netherlands
ID NLM: 101644944
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
entrez:
19
11
2019
pubmed:
19
11
2019
medline:
19
11
2019
Statut:
ppublish
Résumé
Loneliness, or perceived social isolation, may be evident in any group-living species, although its assessment in nonhumans provides some measurement challenges. It is well-known that loneliness in humans confers significant risk for morbidity and mortality, although mechanisms remain unclear. The authors describe a naturally-occurring model of loneliness in adult male rhesus monkeys that shows many parallels with the phenomenon in humans. Lonely monkeys (those that display high frequencies of social initiations but low frequencies of complex interaction) show elevated sympathetic nervous system activity and down regulated Type I interferon responses. Analysis of data from simian immunodeficiency virus-infected monkeys indicates that these physiological changes have functional consequences. Use of this animal model can help identify mechanisms by which loneliness impacts health.
Identifiants
pubmed: 31737750
doi: 10.1016/j.cobeha.2019.01.013
pmc: PMC6857932
mid: NIHMS1522914
doi:
Types de publication
Journal Article
Langues
eng
Pagination
51-57Subventions
Organisme : NIH HHS
ID : P51 OD011107
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG033590
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG033590
Pays : United States
Déclaration de conflit d'intérêts
Declarations of interest: none
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