The retinal choroid as an oculovascular biomarker for Alzheimer's dementia: A histopathological study in severe disease.
Alzheimer's disease
Biomarker
Choroid
Histopathology
Morphometric analysis
Retina
Vascular biomarkers
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
19
11
2019
pubmed:
19
11
2019
medline:
19
11
2019
Statut:
epublish
Résumé
Previous Human postmortem tissues from 8 patients with AD (mean age: 80.1 ± 12.7 years) and from 11 age-matched controls (mean age: 78.4 ± 16.57 years) were analyzed. Thickness, area, and vascularity of the retinal choroid and its sublayers were measured from the nasal and temporal quadrants of the superior retina. Nasally, the choroid was thinner in the patients with AD than in the controls (22% thickness reduction; We found significant differences in the retinal choroid by layer and by region, nasally and temporally with respect to the optic nerve. Intriguingly, the choroid was markedly thicker in the central macular region and was strongly associated with vessel number in the stromal vascular layer. These quantified histological findings in severe disease expand our understanding of vascular pathology in AD and suggest vascularity as a potential biomarker supplementary to thickness when evaluating the retinal choroid in AD.
Identifiants
pubmed: 31737776
doi: 10.1016/j.dadm.2019.08.005
pii: S2352-8729(19)30063-6
pmc: PMC6849152
doi:
Types de publication
Journal Article
Langues
eng
Pagination
775-783Subventions
Organisme : NIA NIH HHS
ID : P50 AG005142
Pays : United States
Informations de copyright
© 2019 The Authors.
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