Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer.
NTRK gene fusions
TRK
TRK fusion cancer
tropomyosin receptor kinase
Journal
Annals of oncology : official journal of the European Society for Medical Oncology
ISSN: 1569-8041
Titre abrégé: Ann Oncol
Pays: England
ID NLM: 9007735
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
entrez:
19
11
2019
pubmed:
19
11
2019
medline:
9
7
2020
Statut:
ppublish
Résumé
The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by NTRK genes and have a role in the development and normal functioning of the nervous system. Since the discovery of an oncogenic NTRK gene fusion in colorectal cancer in 1986, over 80 different fusion partner genes have been identified in a wide array of adult and paediatric tumours, providing actionable targets for targeted therapy. This review describes the normal function and physiology of TRK receptors and the biology behind NTRK gene fusions and how they act as oncogenic drivers in cancer. Finally, an overview of the incidence and prevalence of NTRK gene fusions in various types of cancers is discussed.
Identifiants
pubmed: 31738427
pii: S0923-7534(19)55117-1
doi: 10.1093/annonc/mdz383
pmc: PMC6859819
doi:
pii:
Substances chimiques
Oncogene Proteins, Fusion
0
Protein Kinases
EC 2.7.-
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
Receptor, trkA
EC 2.7.10.1
tropomyosin kinase
EC 2.7.11.28
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
viii5-viii15Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology.
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