FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis.
Cerebrospinal fluid
FilmArray Meningitis/Encephalitis
Meningitis
Polymerase chain reaction
Journal
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
ISSN: 1678-4391
Titre abrégé: Braz J Infect Dis
Pays: Brazil
ID NLM: 9812937
Informations de publication
Date de publication:
Historique:
received:
08
07
2019
revised:
30
09
2019
accepted:
20
10
2019
pubmed:
19
11
2019
medline:
7
3
2020
entrez:
19
11
2019
Statut:
ppublish
Résumé
The precise diagnosis of bacterial meningitis is essential. Cytological and biochemical examination of cerebrospinal fluid (CSF) are not specific. Conventional methods for bacterial meningitis lack sensitivity or take too long for a final result. Therefore, other methods for rapid and accurate diagnosis of central nervous system infections are required. FilmArray meningitis/encephalitis (ME) panel is a PCR multiplex for simultaneous and rapid identification of 14 pathogens, including 6 bacteria, 7 viruses, and Cryptococcus. We evaluated 436 CSF samples submitted to FilmArray ME Panel. Among them, 25 cases were positive for bacteria, being Streptococcus pneumonia the most frequent (48 %). Among positive cases for bacteria, 60 % were positive only with FilmArray. All the bacterial meningitis cases in which the only positive test was FilmArray had CSF findings suggestive of bacterial meningitis, including neutrophilic pleocytosis, increased CSF protein and lactate, and decreased CSF glucose. These findings suggest that FilmArray may increase the diagnostic sensitivity for bacterial meningitis.
Identifiants
pubmed: 31738885
pii: S1413-8670(19)30474-X
doi: 10.1016/j.bjid.2019.10.008
pmc: PMC9428239
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
468-470Informations de copyright
Copyright © 2019 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.
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