Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities.
Biological Products
/ chemical synthesis
Dose-Response Relationship, Drug
Humans
Hydrogen Peroxide
/ antagonists & inhibitors
Molecular Structure
Monoamine Oxidase
/ metabolism
Monoamine Oxidase Inhibitors
/ chemical synthesis
Neuroprotective Agents
/ chemical synthesis
Phenols
/ chemical synthesis
Quinones
/ chemical synthesis
Structure-Activity Relationship
Tumor Cells, Cultured
Derivatization
Fungal metabolites
MAO-B
Neogrifolin
SH-SY5Y cells
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
19
07
2019
revised:
04
10
2019
accepted:
05
10
2019
pubmed:
20
11
2019
medline:
28
1
2021
entrez:
20
11
2019
Statut:
ppublish
Résumé
Twenty-seven natural product-like polyprenylated phenols and quinones were synthesized and their neuroprotective activity was tested using human monoamine oxidase B (MAO-B) and SH-SY5Y cells. Eight compounds inhibited MAO-B (IC
Identifiants
pubmed: 31740200
pii: S0968-0896(19)31230-1
doi: 10.1016/j.bmc.2019.115156
pii:
doi:
Substances chimiques
Biological Products
0
Monoamine Oxidase Inhibitors
0
Neuroprotective Agents
0
Phenols
0
Quinones
0
Hydrogen Peroxide
BBX060AN9V
Monoamine Oxidase
EC 1.4.3.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115156Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.