Threat imminence dictates the role of the bed nucleus of the stria terminalis in contextual fear.
Anxiety
Bed nucleus of the stria terminalis
Context
Fear
Rat
Journal
Neurobiology of learning and memory
ISSN: 1095-9564
Titre abrégé: Neurobiol Learn Mem
Pays: United States
ID NLM: 9508166
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
11
08
2019
revised:
09
11
2019
accepted:
13
11
2019
pubmed:
20
11
2019
medline:
23
1
2021
entrez:
20
11
2019
Statut:
ppublish
Résumé
Recent work indicates that the bed nucleus of the stria terminalis (BNST) is critically involved in the regulation of conditioned fear responses to unpredictable threats. Here we examined whether the involvement of the BNST in contextual fear conditioning in male rats depends on the imminence of shock after placement in the conditioning chamber. Specifically, we hypothesized that the BNST supports contextual freezing after conditioning with delayed, but not imminent, footshock (relative to placement in the context). Rats were implanted with cannulae targeting the BNST and underwent a contextual fear conditioning procedure in which a single footshock unconditioned stimulus (US) was delivered either 1 min or 9 min after the rat was placed in the context; the rats received a total of four identical conditioning sessions over two days, all with equivalent exposure to the context. Contexts associated with either imminent or delayed US onsets produced distinct patterns of freezing and shock-induced activity but freezing in each case was context-dependent. Reversible inactivation of the BNST reduced the expression of contextual freezing in the context paired with delayed (9 min), but not imminent (1 min), footshock onset. Implications of these data are discussed in the light of recent conceptualizations of BNST function, as well as for anxiety behaviors.
Identifiants
pubmed: 31740383
pii: S1074-7427(19)30183-2
doi: 10.1016/j.nlm.2019.107116
pmc: PMC6980749
mid: NIHMS1545313
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107116Subventions
Organisme : NIMH NIH HHS
ID : F31 MH107113
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH065961
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117852
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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