Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine
Acyltransferases
/ antagonists & inhibitors
Cell Line, Tumor
Cell Proliferation
Coculture Techniques
Culture Media, Conditioned
/ chemistry
Fulvestrant
/ pharmacology
Humans
Intracellular Signaling Peptides and Proteins
/ antagonists & inhibitors
Membrane Proteins
/ antagonists & inhibitors
Paracrine Communication
Protein Transport
RNA Interference
RNA, Small Interfering
/ metabolism
Receptors, G-Protein-Coupled
/ antagonists & inhibitors
Wnt Signaling Pathway
/ drug effects
Wnt3A Protein
/ antagonists & inhibitors
Wnt4 Protein
/ antagonists & inhibitors
PORCN
WNT3A
WNT4
Wnt pathway
Wnt signaling
breast cancer
cancer biology
cell growth
cell signaling
glycoprotein secretion
ovarian cancer
protein secretion
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
27 12 2019
27 12 2019
Historique:
received:
30
05
2019
revised:
16
10
2019
pubmed:
20
11
2019
medline:
23
6
2020
entrez:
20
11
2019
Statut:
ppublish
Résumé
Porcupine
Identifiants
pubmed: 31740580
pii: S0021-9258(20)30017-X
doi: 10.1074/jbc.RA119.009615
pmc: PMC6937561
doi:
Substances chimiques
Culture Media, Conditioned
0
Intracellular Signaling Peptides and Proteins
0
Membrane Proteins
0
RNA, Small Interfering
0
Receptors, G-Protein-Coupled
0
WLS protein, human
0
Wnt3A Protein
0
Wnt4 Protein
0
Fulvestrant
22X328QOC4
Acyltransferases
EC 2.3.-
PORCN protein, human
EC 2.3.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19950-19966Subventions
Organisme : NCI NIH HHS
ID : K99 CA193734
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA193734
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA194318
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007635
Pays : United States
Informations de copyright
© 2019 Rao et al.
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