Comparative genetic architectures of schizophrenia in East Asian and European populations.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
09
01
2019
accepted:
10
09
2019
pubmed:
20
11
2019
medline:
18
1
2020
entrez:
20
11
2019
Statut:
ppublish
Résumé
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations.
Identifiants
pubmed: 31740837
doi: 10.1038/s41588-019-0512-x
pii: 10.1038/s41588-019-0512-x
pmc: PMC6885121
mid: NIHMS1539625
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1670-1678Subventions
Organisme : NHGRI NIH HHS
ID : U54 HG003067
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK114379
Pays : United States
Organisme : Medical Research Council
ID : MR/P005748/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U01 MH109536
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109514
Pays : United States
Organisme : NIMH NIH HHS
ID : K99 MH117229
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109532
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109539
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI139012
Pays : United States
Organisme : Medical Research Council
ID : G0800509
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U01 MH109528
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085560
Pays : United States
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH085521
Pays : United States
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