Genetic polymorphisms influence gene expression of human periodontal ligament fibroblasts in the early phases of orthodontic tooth movement.
Bone
Connective tissue
Genetic polymorphism
Orthodontics
Periodontal ligament
Journal
Odontology
ISSN: 1618-1255
Titre abrégé: Odontology
Pays: Japan
ID NLM: 101134822
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
16
06
2019
accepted:
31
10
2019
pubmed:
20
11
2019
medline:
29
5
2020
entrez:
20
11
2019
Statut:
ppublish
Résumé
Genetic polymorphisms could be involved in the individual rate of OTM (orthodontic tooth movement) corresponding to the clinical phenomenon of "slow movers" and "fast movers". This study evaluated, if genetic polymorphisms in RANK, RANKL, OPG, COX2 and IL6 are associated with the expression of RANKL, OPG, COX2 and IL6 by human periodontal ligament (hPDL) fibroblasts during OTM. Primary hPDL fibroblasts from periodontal connective tissue of teeth extracted from 57 human subjects for medical reasons were collected, isolated, cultivated and characterized. To simulate orthodontic forces in PDL pressure areas, a physiological compressive force of 2 g/cm
Identifiants
pubmed: 31741103
doi: 10.1007/s10266-019-00475-x
pii: 10.1007/s10266-019-00475-x
doi:
Substances chimiques
Osteoprotegerin
0
RANK Ligand
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
493-502Subventions
Organisme : Bavarian University Centre for Latin America BAYLAT
ID : Kirschneck 12/2017
Organisme : Fundação Amazônia Paraense de Amparo à Pesquisa
ID : Küchler 2015/06866-5