Effect of dissection on the mechanical properties of human ascending aorta and human ascending aorta aneurysm.

The aim of the presented work is to determine (i) mechanical properties of the ascending aorta wall (DAA) and the wall of the ascending aortic aneurysm (DAAA), in which spontaneous dissection resulting from the evolving disease occurred, and (ii) the strength of the interface between the layers in the above-mentioned vessels. The mechanical tests were divided into two steps. In the first step the mechanical properties of the of DAA and DAAA walls were examined on the basis of uniaxial stretching until rapture. In the next step the mechanical parameters of the interface between layers of DAA and DAAA walls were determined by the peeling test. Higher values of tensile strength (  max) and Young's modulus (E) were obtained for the DAAA group, to which the dissecting wall of the ascending aortic aneurysm was classified. For circumferential samples, the difference between the DAAA and DAA groups was 39% in the case of tensile strength and 70% in the case of the Young's modulus. Summarizing, the studies performed showed that the dissection process is different in the case of the ascending aortic aneurysm wall and the ascending aorta wall. The wall of the ascending aortic aneurysm is more susceptible to dissection, as evidenced by lower values of the mechanical parameters of the interface between the intima and the media-adventitia complex. The obtained results of mechanical properties tests confirm that dissection and aneurysm should be treated as separate disease entities that may coexist with each other.