Electroencephalography in Primary Progressive Aphasia and Apraxia of Speech.
Electroencephalography (EEG)
Frontotemporal dementia
Primary Progressive Aphasia
Primary Progressive Apraxia of Speech
Journal
Aphasiology
ISSN: 0268-7038
Titre abrégé: Aphasiology
Pays: England
ID NLM: 8708531
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
20
11
2019
pubmed:
20
11
2019
medline:
20
11
2019
Statut:
ppublish
Résumé
Past research has demonstrated that electroencephalography (EEG) is sensitive to what we now know as Primary Progressive Aphasia (PPA); however, the EEG profiles of patients with Primary Progressive Apraxia of Speech (PPAOS) and PPA, in the context of current consensus criteria, have not been studied. The primary goal of this study was to explore the EEG profiles of patients of the nonfluent/ agrammatic variant of PPA (agPPA) and PPAOS. Three patients with agPPA and five patients with PPAOS (two with aphasia) completed a head MRI scan and clinical EEG recording. Clinical radiologists and electrophysiologists reviewed respective imaging, blinded to clinical diagnosis. Patients with PPAOS who did not have aphasia had normal EEGs, while those with aphasia demonstrated theta slowing. Patients with agPPA also showed theta slowing, with one exception. MRI scans showed non-specific, age-related changes across clinical presentations. This preliminary study suggests theta slowing is consistent with neurodegenerative aphasia, but not isolated apraxia of speech. EEG is a low-cost mechanism to identify possible biomarkers for use when clinical severity limits behavioral examinations or expert examiners are unavailable.
Sections du résumé
BACKGROUND
BACKGROUND
Past research has demonstrated that electroencephalography (EEG) is sensitive to what we now know as Primary Progressive Aphasia (PPA); however, the EEG profiles of patients with Primary Progressive Apraxia of Speech (PPAOS) and PPA, in the context of current consensus criteria, have not been studied.
AIMS
OBJECTIVE
The primary goal of this study was to explore the EEG profiles of patients of the nonfluent/ agrammatic variant of PPA (agPPA) and PPAOS.
METHODS AND PROCEDURES
METHODS
Three patients with agPPA and five patients with PPAOS (two with aphasia) completed a head MRI scan and clinical EEG recording. Clinical radiologists and electrophysiologists reviewed respective imaging, blinded to clinical diagnosis.
OUTCOMES AND RESULTS
RESULTS
Patients with PPAOS who did not have aphasia had normal EEGs, while those with aphasia demonstrated theta slowing. Patients with agPPA also showed theta slowing, with one exception. MRI scans showed non-specific, age-related changes across clinical presentations.
CONCLUSIONS
CONCLUSIONS
This preliminary study suggests theta slowing is consistent with neurodegenerative aphasia, but not isolated apraxia of speech. EEG is a low-cost mechanism to identify possible biomarkers for use when clinical severity limits behavioral examinations or expert examiners are unavailable.
Identifiants
pubmed: 31741547
doi: 10.1080/02687038.2018.1545991
pmc: PMC6860920
mid: NIHMS1520224
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1410-1417Subventions
Organisme : NIDCD NIH HHS
ID : L30 DC014830
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC012519
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014942
Pays : United States
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