Characterizing CD44 regulatory microRNAs as putative therapeutic agents in human melanoma.
CD44
CD44v6
immune cell infiltration
melanoma
microRNA
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
05 Nov 2019
05 Nov 2019
Historique:
received:
09
08
2019
accepted:
21
10
2019
entrez:
20
11
2019
pubmed:
20
11
2019
medline:
20
11
2019
Statut:
epublish
Résumé
The multistructural and multifunctional transmembrane glycoprotein CD44 is overexpressed in many tumors of distinct origin including malignant melanoma and contributes to a poor prognosis by affecting cell proliferation, cell migration, and also the sensitivity for apoptosis induction. Previous studies reported so far 15 CD44 regulatory microRNAs (miRs) in different cell systems. Using a novel method for miR affinity purification miR-143-3p was identified as most potent binder to the 3' untranslated region (UTR) of CD44. Overexpression of miR-143-3p in melanoma cells inhibits CD44 translation, which is accompanied by a reduced proliferation, migration and enhanced daunorubicin induced apoptosis of melanoma cells
Identifiants
pubmed: 31741714
doi: 10.18632/oncotarget.27305
pii: 27305
pmc: PMC6849650
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6509-6525Déclaration de conflit d'intérêts
Conflicts of interest The authors declare that they have no competing interests.
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