Targeting the TIGIT-PVR immune checkpoint axis as novel therapeutic option in breast cancer.
PVR
TIGIT
breast cancer
immunotherapy
Journal
Oncoimmunology
ISSN: 2162-4011
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
Historique:
received:
17
07
2019
revised:
30
08
2019
accepted:
25
09
2019
entrez:
20
11
2019
pubmed:
20
11
2019
medline:
20
11
2019
Statut:
epublish
Résumé
Immune checkpoints are intensively investigated as targets in cancer therapy. T-cell immunoreceptor with immunoglobulin (Ig) and ITIM domains (TIGIT) and its ligand poliovirus receptor (PVR) are recently emerging as novel promising targets in immunotherapy. Here, we show that high expression of PVR represents an independent prognostic marker being associated with poor outcome for breast cancer patients. Furthermore, PVR mRNA, as well as protein expression, is associated with more aggressive breast cancer subtypes such as HER2 positive and triple-negative breast cancer.
Identifiants
pubmed: 31741778
doi: 10.1080/2162402X.2019.1674605
pii: 1674605
pmc: PMC6844319
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
e1674605Informations de copyright
© 2019 Taylor & Francis Group, LLC.
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