Association of leukemia and mitochondrial diseases-A review.
Leukemia
mitochondrial DNA
oxidative phosphorylation
Journal
Journal of family medicine and primary care
ISSN: 2249-4863
Titre abrégé: J Family Med Prim Care
Pays: India
ID NLM: 101610082
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
23
08
2019
revised:
23
08
2019
accepted:
19
09
2019
entrez:
20
11
2019
pubmed:
20
11
2019
medline:
20
11
2019
Statut:
epublish
Résumé
Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in cellular energy (ATP) production because of impaired oxidative phosphorylation is the most important cause for these underlying disorders. The present review article aims to provide current understanding of mitochondrial genetics and biology and relates the mt-DNA alterations in leukemia patients.
Identifiants
pubmed: 31742129
doi: 10.4103/jfmpc.jfmpc_679_19
pii: JFMPC-8-3120
pmc: PMC6857401
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
3120-3124Informations de copyright
Copyright: © 2019 Journal of Family Medicine and Primary Care.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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