The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4.

1-Acylglycerol-3-Phosphate O-Acyltransferase / metabolism 3T3-L1 Cells Animals Heart Failure / prevention & control Histone Deacetylases / metabolism Humans Lipid Droplets Mice Protein Binding Proteolysis Repressor Proteins / metabolism Serine Proteases / metabolism

Journal

Nature metabolism

ISSN: 2522-5812

Titre abrégé: Nat Metab

Pays: Germany

ID NLM: 101736592

Informations de publication

Date de publication:
11 2019

Historique:

entrez: 20 11 2019

pubmed: 20 11 2019

medline: 20 11 2019

Statut: ppublish

Résumé

Catecholamines stimulate the first step of lipolysis by PKA-dependent release of the lipid droplet-associated protein ABHD5 from perilipin to co-activate the lipase ATGL. Here, we unmask a yet unrecognized proteolytic and cardioprotective function of ABHD5. ABHD5 acts

Identifiants

DOI: 10.1038/s42255-019-0138-4 PMID: 31742248 PMC: PMC6861130

pubmed: 31742248

doi: 10.1038/s42255-019-0138-4

pmc: PMC6861130

mid: EMS84593

pii: 10.1038/s42255-019-0138-4

doi:

Substances chimiques

Repressor Proteins 0

1-Acylglycerol-3-Phosphate O-Acyltransferase EC 2.3.1.51

ABHD5 protein, human EC 2.3.1.51

Serine Proteases EC 3.4.-

HDAC4 protein, human EC 3.5.1.98

Histone Deacetylases EC 3.5.1.98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

1157-1167

Subventions

Organisme : Austrian Science Fund FWF

ID : F 7303

Pays : Austria

Organisme : Austrian Science Fund FWF

ID : P 24857

Pays : Austria

Déclaration de conflit d'intérêts

Competing Interests Statement Z.H.J., L.H.L, O.J.M, H.A.K. and J.B. filed a patent on HDAC4-NT and ABHD5 gene therapy (US9914912B2). All other authors declare no conflict of interest.

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