α-Synuclein in blood cells differentiates Parkinson's disease from healthy controls.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
04
06
2019
revised:
05
10
2019
accepted:
09
10
2019
pubmed:
20
11
2019
medline:
2
10
2020
entrez:
20
11
2019
Statut:
ppublish
Résumé
To determine whether blood cells expressed α-Syn can differentiate Parkinson's disease (PD) from healthy controls (HC). The concentrations of α-Syn were determined in samples of blood cell pellets using a quantitative Lipid-ELISA assay. In addition, the levels of total protein, hemoglobin, iron and H-ferritin were determined. The study includes samples from the Biofind cohort (n = 46 PD and 45 HC) and results were validated with an additional cohort (n = 35 PD and 28 HC). A composite biomarker consisting of the concentrations of total α-Syn, proteinase-K resistant (PK Our results demonstrate the potential usefulness of blood cells expressed α-Syn as a biomarker for PD.
Identifiants
pubmed: 31742923
doi: 10.1002/acn3.50944
pmc: PMC6917335
doi:
Substances chimiques
Biomarkers
0
SNCA protein, human
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2426-2436Subventions
Organisme : NINDS NIH HHS
ID : U24 NS095871
Pays : United States
Organisme : Michael J. Fox Foundation
ID : 11899
Pays : International
Informations de copyright
© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
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