Does the Functional Liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predict Outcomes in Chronic Liver Disease?

Adult Chronic Disease Contrast Media Female Gadolinium DTPA Humans Image Enhancement / methods Liver / diagnostic imaging Liver Diseases / diagnostic imaging Magnetic Resonance Imaging / methods Male Middle Aged Predictive Value of Tests Reproducibility of Results Retrospective Studies

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
01 2020
Historique:
pubmed: 20 11 2019
medline: 21 4 2020
entrez: 20 11 2019
Statut: ppublish

Résumé

Background Gadoxetic acid-enhanced MRI enables estimation of liver function in patients with chronic liver disease (CLD). The functional liver imaging score (FLIS), derived from gadoxetic acid-enhanced MRI, has been shown to predict transplant-free survival in liver transplant patients. Purpose To investigate the accuracy of the FLIS for predicting hepatic decompensation and transplant-free survival in patients with CLD. Materials and Methods Patients with CLD who had undergone gadoxetic acid-enhanced liver MRI, including T1-weighted volume-interpolated breath-hold examination sequences with fat suppression, performed between 2011 and 2015 were included. FLIS was assigned on the basis of the sum of three hepatobiliary phase features, each scored on an ordinal 0-2 scale: hepatic enhancement, biliary excretion, and the signal intensity in the portal vein. Patients were stratified into the following three groups according to fibrosis stage and a presence or history of hepatic decompensation: nonadvanced CLD, compensated advanced CLD (CACLD), and decompensated advanced CLD (DACLD). The predictive value of FLIS for first and/or further hepatic decompensation and for transplant-free survival was investigated by using Kaplan-Meier analysis, log-rank tests, and Cox regression analysis. Results This study evaluated 265 patients (53 years ± 14 [standard deviation]; 164 men). Intraobserver (κ = 0.98; 95% confidence interval: 0.97, 0.99) and interobserver (κ = 0.93; 95% confidence interval: 0.90, 0.95) agreement for FLIS were excellent. In patients with CACLD, the FLIS was independently predictive of a first hepatic decompensation (adjusted hazard ratio, 3.7; 95% confidence interval: 1.1, 12.6;

Identifiants

DOI: 10.1148/radiol.2019190734 PMID: 31743083
pubmed: 31743083
doi: 10.1148/radiol.2019190734
doi:

Substances chimiques

Contrast Media 0
gadolinium ethoxybenzyl DTPA 0
Gadolinium DTPA K2I13DR72L

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

98-107

Auteurs

Nina Bastati (N)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0002-3994-6552

Lucian Beer (L)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0003-4388-7580

Mattias Mandorfer (M)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0003-2330-0017

Sarah Poetter-Lang (S)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0002-8843-0958

Dietmar Tamandl (D)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0003-1996-0688

Yesim Bican (Y)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0001-8444-8491

Michael Christoph Elmer (MC)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0001-8158-1430

Henrik Einspieler (H)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0003-0233-4840

Georg Semmler (G)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0002-0411-166X

Benedikt Simbrunner (B)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0001-8181-9146

Michael Weber (M)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0002-8507-2219

Jacqueline C Hodge (JC)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0003-1190-4120

Federica Vernuccio (F)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0003-0350-1794

Claude Sirlin (C)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0002-6639-9072

Thomas Reiberger (T)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0002-4590-3583

Ahmed Ba-Ssalamah (A)

From the Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Waehringer Guertel 18-20, A-1090 Vienna, Austria (N.B., L.B., S.P.L., D.T., Y.B., M.C.E., H.E., M.W., J.C.H., A.B.); Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (M.M., G.S., B.S., T.R.); Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy (F.V.); and Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, Calif (C.S.).
ORCID: 0000-0002-3527-404X

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Does the Functional Liver Imaging Score...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits de contraste › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Acide gadopentétique › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement d'image par ordinateur › Amélioration d'image › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Système digestif › Foie › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Does the Functional Liver Imaging Score...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Does the Functional Liver Imaging Score...