HEPA filtration improves asthma control in children exposed to traffic-related airborne particles.
PM2.5
asthma control questionnaire
asthma quality of life questionnaire
black carbon
high-efficiency particulate air filter
Journal
Indoor air
ISSN: 1600-0668
Titre abrégé: Indoor Air
Pays: England
ID NLM: 9423515
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
21
06
2019
revised:
18
10
2019
accepted:
14
11
2019
pubmed:
20
11
2019
medline:
22
4
2020
entrez:
20
11
2019
Statut:
ppublish
Résumé
Traffic-related airborne particles are associated with asthma morbidity. The aim of this study was to assess the impact of a high-efficiency particulate air (HEPA) filtration on the concentrations of traffic particles and the resultant effect on children with asthma. Forty-three children with asthma were enrolled in this double-blind, placebo-controlled crossover design. A HEPA air cleaner or a placebo "dummy" was placed in participants' homes for four weeks, interrupted by a one-month washout period, before crossing over to the other treatment arm for four weeks. Air sampling and health outcomes, including asthma control (ACQ) and quality of life (AQLQ) measures, were completed prior to and at the end of each treatment arm. Indoor concentrations of traffic particles were significantly reduced with the HEPA treatment but not with the "dummy" treatment. In participants with poorly controlled asthma and lower quality of life at baseline, ACQ and AQLQ scores were significantly improved (1.3 to 0.9, P = .003 and 4.9 to 5.5, P = .02, respectively) following the HEPA treatment. In this study, HEPA filtration is associated with improved clinical outcomes and quality of life measures in children with uncontrolled asthma.
Identifiants
pubmed: 31743467
doi: 10.1111/ina.12625
pmc: PMC7895332
mid: NIHMS1669113
doi:
Substances chimiques
Particulate Matter
0
Vehicle Emissions
0
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
235-243Subventions
Organisme : NIEHS NIH HHS
ID : T32 ES010957
Pays : United States
Organisme : NIEHS NIH HHS
ID : 2T32ES010957
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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