Dietary modification reduces serum angiopoietin-like protein 2 levels and arterial stiffness in overweight and obese men.
ANGPTL2
Journal
Journal of exercise nutrition & biochemistry
ISSN: 2233-6834
Titre abrégé: J Exerc Nutrition Biochem
Pays: Korea (South)
ID NLM: 101572566
Informations de publication
Date de publication:
30 Sep 2019
30 Sep 2019
Historique:
received:
16
09
2019
accepted:
28
09
2019
entrez:
21
11
2019
pubmed:
21
11
2019
medline:
21
11
2019
Statut:
ppublish
Résumé
Weight loss can reduce obesity-induced arterial stiffening that is attributed to decreased inflammation. Angiopoietin-like protein 2 (ANGPTL2) is a pro-inflammatory adipokine that is upregulated in obesity and is important in the progression of atherosclerosis and cardiovascular disease. The purpose of this study is to investigate the effects of dietary modification on circulating ANGPTL2 levels and arterial stiffness in overweight and obese men. Twenty-two overweight and obese men (with mean age of 56 ± 2 years and body mass index of 28.6 ± 2.6 kg/m2) completed a 12-week dietary modification program. We measured the arterial compliance and β-stiffness index (as the indices of arterial stiffness) and serum ANGPTL2 levels before and after the program. After the 12-week dietary modification, body mass and daily energy intake were significantly reduced. Arterial compliance was significantly increased and β-stiffness index was significantly decreased after the 12-week dietary modification program. Serum ANGPTL2 levels were significantly decreased. Also, the changes in arterial compliance were negatively correlated with the changes in serum ANGPTL2 levels, whereas the changes in β-stiffness index were positively correlated with the changes in serum ANGPTL2 levels. These results suggest that the decrease in circulating ANGPTL2 levels can be attributed to the dietary modification-induced reduction of arterial stiffness in overweight and obese men.
Identifiants
pubmed: 31743976
pii: JENB_2019_v23n3
doi: 10.20463/jenb.2019.0021
pmc: PMC6823644
doi:
Types de publication
Journal Article
Langues
eng
Pagination
39-44Informations de copyright
©2019 The Korean Society for Exercise Nutrition.
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