Reiber's Diagram for Kappa Free Light Chains: The New Standard for Assessing Intrathecal Synthesis?
Reiber’s diagram
biomarker
cerebrospinal fluid
hyperbolic function
kappa free light chains
multiple sclerosis
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
16 Nov 2019
16 Nov 2019
Historique:
received:
03
10
2019
revised:
01
11
2019
accepted:
12
11
2019
entrez:
21
11
2019
pubmed:
21
11
2019
medline:
21
11
2019
Statut:
epublish
Résumé
Oligoclonal bands are the gold standard for determination of an intrathecal immunoglobulin G synthesis and were recently included in the McDonald criteria of 2017 to diagnose relapsing multiple sclerosis (MS) as a substitute for dissemination in time. Intrathecally produced kappa free light chains (KFLC) are a novel promising biomarker with similar characteristics and the advantage for automated determination. However, different approaches exist to determine the intrathecal KFLC fraction. The most common method is to calculate the CSF/serum KFLC quotient with reference to the albumin CSF/serum quotient (Q
Identifiants
pubmed: 31744096
pii: diagnostics9040194
doi: 10.3390/diagnostics9040194
pmc: PMC6963502
pii:
doi:
Types de publication
Journal Article
Langues
eng
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