Pulsed Electromagnetic Field Therapy Improves Osseous Consolidation after High Tibial Osteotomy in Elderly Patients-A Randomized, Placebo-Controlled, Double-Blind Trial.

bone specific alkaline phosphatase (BAP) elderly extremely low frequency pulsed electromagnetic field (ELF-PEMF) therapy high tibial osteotomy (HTO) osseous consolidation

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
17 Nov 2019
Historique:
received: 30 10 2019
revised: 13 11 2019
accepted: 15 11 2019
entrez: 21 11 2019
pubmed: 21 11 2019
medline: 21 11 2019
Statut: epublish

Résumé

Extremely low-frequency pulsed electromagnetic field (ELF-PEMF) therapy is proposed to support bone healing after injuries and surgical procedures, being of special interest for elderly patients. This study aimed at investigating the effect of a specific ELF-PEMF, recently identified to support osteoblast function in vitro, on bone healing after high tibial osteotomy (HTO). Patients who underwent HTO were randomized to ELF-PEMF or placebo treatment, both applied by optically identical external devices 7 min per day for 30 days following surgery. Osseous consolidation was evaluated by post-surgical X-rays (7 and 14 weeks). Serum markers were quantified by ELISA. Data were compared by a two-sided t-test (α = 0.05). Device readouts showed excellent therapy compliance. Baseline parameters, including age, sex, body mass index, wedge height and blood cell count, were comparable between both groups. X-rays revealed faster osseous consolidation for ELF-PEMF compared to placebo treatment, which was significant in patients ≥50 years (∆

Identifiants

DOI: 10.3390/jcm8112008 PMID: 31744243 PMC: PMC6912342
pubmed: 31744243
pii: jcm8112008
doi: 10.3390/jcm8112008
pmc: PMC6912342
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Sachtleben GmbH
ID : D3111865

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Auteurs

Patrick Ziegler (P)

Siegfried Weller Institute for Trauma Research, Department of Trauma and Reconstructive Surgery, BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.

Andreas K Nussler (AK)

Siegfried Weller Institute for Trauma Research, Department of Trauma and Reconstructive Surgery, BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
ORCID: 0000-0002-6666-6791

Benjamin Wilbrand (B)

Siegfried Weller Institute for Trauma Research, Department of Trauma and Reconstructive Surgery, BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.

Karsten Falldorf (K)

Sachtleben GmbH, Haus Spectrum am UKE, Martinistraße 64, D-20251 Hamburg, Germany.

Fabian Springer (F)

Department of Diagnostic and Interventional Radiology, University of Tübingen, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany.

Anne-Kristin Fentz (AK)

Sachtleben GmbH, Haus Spectrum am UKE, Martinistraße 64, D-20251 Hamburg, Germany.

Georg Eschenburg (G)

Sachtleben GmbH, Haus Spectrum am UKE, Martinistraße 64, D-20251 Hamburg, Germany.
ORCID: 0000-0003-2857-5239

Andreas Ziegler (A)

StatSol Lübeck, Moenring 2, D-23560 Lübeck, Germany.
School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, Scottsville 3209, South Africa.
ORCID: 0000-0002-8386-5397

Ulrich Stöckle (U)

Center for Musculoskeletal Surgery, Charité-University Medicine Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany.

Elke Maurer (E)

Siegfried Weller Institute for Trauma Research, Department of Trauma and Reconstructive Surgery, BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.

Atesch Ateschrang (A)

Siegfried Weller Institute for Trauma Research, Department of Trauma and Reconstructive Surgery, BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.

Steffen Schröter (S)

Siegfried Weller Institute for Trauma Research, Department of Trauma and Reconstructive Surgery, BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.

Sabrina Ehnert (S)

Siegfried Weller Institute for Trauma Research, Department of Trauma and Reconstructive Surgery, BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.

Classifications MeSH