The role of childhood BMI in predicting early adulthood dysglycemia: Tehran lipid and glucose study.
Adult
Age Factors
Biomarkers
/ blood
Blood Glucose
/ analysis
Body Mass Index
Child
Child, Preschool
Diabetes Mellitus, Type 2
/ blood
Female
Follow-Up Studies
Humans
Incidence
Iran
/ epidemiology
Lipids
/ blood
Male
Pediatric Obesity
/ blood
Prediabetic State
/ blood
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Young Adult
Adulthood
Childhood
Dysglycemia
Obesity
Overweight
Pre-diabetes
Type 2 diabetes
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
ISSN: 1590-3729
Titre abrégé: Nutr Metab Cardiovasc Dis
Pays: Netherlands
ID NLM: 9111474
Informations de publication
Date de publication:
10 02 2020
10 02 2020
Historique:
received:
15
05
2019
revised:
07
08
2019
accepted:
19
09
2019
pubmed:
21
11
2019
medline:
25
8
2020
entrez:
21
11
2019
Statut:
ppublish
Résumé
Increased adiposity is associated with insulin resistance and glycemic disturbances. We aimed to determine whether childhood overweight or obesity are independent factors in predicting adulthood dysglycemia (prediabetes or type 2 diabetes). In this population-based cohort study, 1290 normoglycemic subjects aged 3-11 years were followed for incidence of dysglycemia. Cox-proportional hazard models were employed to evaluate the association of obesity and overweight with incidence of dysglycemia by adjustments for age, sex, parental risk factors and baseline individual risk factors. The participants, with a mean age of 7.7 ± 2.5 years, were followed for a median of 14.9 years. During follow up, 158 subjects developed dysglycemia (18 type 2 diabetes, 140 prediabetes), contributing to a total cumulative incidence of 24.7%. The unadjusted HR for developing adult dysglycemia were 1.6 (95% CI; 1.0-2.4) and 1.7 (95% CI; 1.0-3.0) in overweight and obese children, respectively. Further adjustments for age, sex, parental risk factors and baseline individual risk factors changed the results in both overweight and obese children. These findings show that overweight or obesity in childhood have no independent role for developing adulthood dysglycemia.
Sections du résumé
BACKGROUND AND AIM
Increased adiposity is associated with insulin resistance and glycemic disturbances. We aimed to determine whether childhood overweight or obesity are independent factors in predicting adulthood dysglycemia (prediabetes or type 2 diabetes).
METHODS AND RESULTS
In this population-based cohort study, 1290 normoglycemic subjects aged 3-11 years were followed for incidence of dysglycemia. Cox-proportional hazard models were employed to evaluate the association of obesity and overweight with incidence of dysglycemia by adjustments for age, sex, parental risk factors and baseline individual risk factors. The participants, with a mean age of 7.7 ± 2.5 years, were followed for a median of 14.9 years. During follow up, 158 subjects developed dysglycemia (18 type 2 diabetes, 140 prediabetes), contributing to a total cumulative incidence of 24.7%. The unadjusted HR for developing adult dysglycemia were 1.6 (95% CI; 1.0-2.4) and 1.7 (95% CI; 1.0-3.0) in overweight and obese children, respectively. Further adjustments for age, sex, parental risk factors and baseline individual risk factors changed the results in both overweight and obese children.
CONCLUSION
These findings show that overweight or obesity in childhood have no independent role for developing adulthood dysglycemia.
Identifiants
pubmed: 31744715
pii: S0939-4753(19)30378-3
doi: 10.1016/j.numecd.2019.09.026
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
313-319Informations de copyright
Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors claimed that they have no potential conflicts of interest to disclose.