Diet-Induced Modification of the Sperm Epigenome Programs Metabolism and Behavior.
epigenetics
intergenerational paternal effects
metabolic dysfunction
nongenetic inheritance
obesity
sperm epimutation
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
03
06
2019
revised:
10
10
2019
accepted:
11
10
2019
pubmed:
21
11
2019
medline:
4
8
2021
entrez:
21
11
2019
Statut:
ppublish
Résumé
Globally, obesity has reached epidemic proportions. The rapidly increasing numbers of overweight people can be traced back to overconsumption of energy-dense, poor-quality foods as well as physical inactivity. This development has far-reaching and costly implications. Not only is obesity associated with serious physiological and psychological complications, but mounting evidence also indicates a ripple effect through generations via epigenetic changes. Parental obesity could induce intergenerational and transgenerational changes in metabolic and brain function of the offspring. Most research has focused on maternal epigenetic and gestational effects; however, paternal contributions are likely to be substantial. We focus on the latest advances in understanding the mechanisms of epigenetic inheritance of obesity-evoked metabolic and neurobiological changes through the paternal germline that predict wide-ranging consequences for the following generation(s).
Identifiants
pubmed: 31744784
pii: S1043-2760(19)30209-7
doi: 10.1016/j.tem.2019.10.005
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-149Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.