Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension.

Case-Control Studies Erythrocyte Indices Genome-Wide Association Study Humans Hypertension, Pulmonary / genetics Pulmonary Arterial Hypertension

Journal

The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460

Informations de publication

Date de publication:
02 2020
Historique:
received: 25 07 2019
accepted: 29 10 2019
pubmed: 21 11 2019
medline: 22 6 2021
entrez: 21 11 2019
Statut: epublish

Résumé

Pulmonary arterial hypertension (PAH) is a rare disease that leads to premature death from right heart failure. It is strongly associated with elevated red cell distribution width (RDW), a correlate of several iron status biomarkers. High RDW values can signal early-stage iron deficiency or iron deficiency anaemia. This study investigated whether elevated RDW is causally associated with PAH.A two-sample Mendelian randomisation (MR) approach was applied to investigate whether genetic predisposition to higher levels of RDW increases the odds of developing PAH. Primary and secondary MR analyses were performed using all available genome-wide significant RDW variants (n=179) and five genome-wide significant RDW variants that act

Identifiants

DOI: 10.1183/13993003.01486-2019 PMID: 31744833 PMC: PMC7015630
pubmed: 31744833
pii: 13993003.01486-2019
doi: 10.1183/13993003.01486-2019
pmc: PMC7015630
mid: NIHMS1560946
pii:
doi:

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : RC2 GM092618
Pays : United States
Organisme : British Heart Foundation
ID : FS/15/59/31839
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U19 HL065962
Pays : United States
Organisme : NHLBI NIH HHS
ID : R24 HL105333
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD074711
Pays : United States
Organisme : British Heart Foundation
ID : SP/12/12/29836
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS032830
Pays : United States
Organisme : British Heart Foundation
ID : RG/13/4/30107
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/4/34215
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG006378
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002243
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004798
Pays : United States
Organisme : British Heart Foundation
ID : RG/08/006/25302
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K020919/1
Pays : United Kingdom
Organisme : NCRR NIH HHS
ID : UL1 RR024975
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM115305
Pays : United States
Organisme : British Heart Foundation
ID : CH/09/001/25945
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL146588
Pays : United States
Organisme : Wellcome Trust
ID : 204809/Z/16/Z
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL136603
Pays : United States
Organisme : British Heart Foundation
ID : RG/10/16/28575
Pays : United Kingdom
Organisme : NCRR NIH HHS
ID : S10 RR025141
Pays : United States

Informations de copyright

Copyright ©ERS 2020.

Déclaration de conflit d'intérêts

Conflict of interest: A. Ulrich has nothing to disclose. Conflict of interest: J. Wharton has nothing to disclose. Conflict of interest: T.E. Thayer has nothing to disclose. Conflict of interest: E.M. Swietlik has nothing to disclose. Conflict of interest: T.R. Assad has nothing to disclose. Conflict of interest: A.A. Desai has nothing to disclose. Conflict of interest: S. Gräf has nothing to disclose. Conflict of interest: L. Harbaum has nothing to disclose. Conflict of interest: M. Humbert reports grants and personal fees from Bayer and GSK, personal fees from Actelion, Merck and from United Therapeutics, outside the submitted work. Conflict of interest: N.W. Morrell reports personal fees from Actelion and Morphogen-IX, outside the submitted work. Conflict of interest: W.C. Nichols has nothing to disclose. Conflict of interest: F. Soubrier has nothing to disclose. Conflict of interest: L. Southgate has nothing to disclose. Conflict of interest: D-A. Trégouët has nothing to disclose. Conflict of interest: R.C. Trembath reports personal fees for advisory board work from Ipsen Pharmaceuticals, personal fees for non-executive board membership from King's College Hospital NHS Foundation Trust, outside the submitted work. Conflict of interest: E.L. Brittain reports personal fees for advisory board work from Bayer, outside the submitted work. Conflict of interest: M.R. Wilkins reports grants from Vifor Pharma, outside the submitted work. Conflict of interest: I. Prokopenko has nothing to disclose. Conflict of interest: C.J. Rhodes reports personal fees from Actelion, outside the submitted work.

Références

BMJ. 2011 Feb 15;342:d548
pubmed: 21325005
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1788-1792
pubmed: 28684612
Am J Hum Genet. 2001 Jan;68(1):92-102
pubmed: 11115378
Eur Heart J. 2016 Jan 1;37(1):67-119
pubmed: 26320113
Am J Respir Crit Care Med. 2012 Aug 1;186(3):261-72
pubmed: 22679007
Circ Res. 2015 May 8;116(10):1680-90
pubmed: 25767292
N Engl J Med. 1996 May 2;334(18):1145-9
pubmed: 8602179
Stroke. 2018 Dec;49(12):2815-2821
pubmed: 30571402
Lancet. 2012 Mar 31;379(9822):1214-24
pubmed: 22421340
J Card Fail. 2011 Aug;17(8):626-33
pubmed: 21807323
Eur Respir J. 2011 Jun;37(6):1386-91
pubmed: 20884742
Lancet Respir Med. 2016 Apr;4(4):306-22
pubmed: 26975810
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
PLoS Genet. 2019 Dec 12;15(12):e1008489
pubmed: 31830040
Ann Am Thorac Soc. 2019 May;16(5):589-598
pubmed: 30608875
Pulm Circ. 2015 Sep;5(3):466-72
pubmed: 26401247
Int J Epidemiol. 2015 Apr;44(2):379-88
pubmed: 26085674
Am J Cardiol. 2009 Sep 15;104(6):868-72
pubmed: 19733726
PLoS One. 2011;6(7):e21689
pubmed: 21818261
Thorax. 2011 Apr;66(4):326-32
pubmed: 21297151
Heart. 2011 Jul;97(13):1054-60
pubmed: 21558476
Circulation. 2019 May 21;139(21):2386-2398
pubmed: 30776909
BMJ. 2013 Jul 18;347:f4262
pubmed: 23869090
PLoS Med. 2013;10(6):e1001462
pubmed: 23750121
Science. 2001 Apr 20;292(5516):464-8
pubmed: 11292862
Eur Respir J. 2014 Mar;43(3):685-8
pubmed: 24585865
Cell. 2016 Nov 17;167(5):1415-1429.e19
pubmed: 27863252
Lancet. 2002 Jul 6;360(9326):23-33
pubmed: 12114037
Hum Mol Genet. 2014 Sep 15;23(R1):R89-98
pubmed: 25064373
Stat Med. 2008 Apr 15;27(8):1133-63
pubmed: 17886233
Int J Cardiol. 2014 Aug 1;175(2):233-9
pubmed: 24880481
Int J Epidemiol. 2014 Jun;43(3):922-9
pubmed: 24608958
Eur Respir J. 2011 Dec;38(6):1453-60
pubmed: 21478213
Lancet Respir Med. 2019 Mar;7(3):227-238
pubmed: 30527956
Nat Commun. 2018 Apr 12;9(1):1416
pubmed: 29650961
Clin Pharmacol Ther. 2008 Sep;84(3):362-9
pubmed: 18500243
J Am Coll Cardiol. 2011 Jul 12;58(3):300-9
pubmed: 21737024
Nat Commun. 2014 Oct 29;5:4926
pubmed: 25352340
J Appl Physiol (1985). 2002 Jun;92(6):2501-7
pubmed: 12015365
J Physiol. 2008 Dec 15;586(24):5999-6005
pubmed: 18955380
Lancet Respir Med. 2016 Feb;4(2):129-37
pubmed: 26795434

Auteurs

Anna Ulrich (A)

National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK.

John Wharton (J)

National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK.

Timothy E Thayer (TE)

Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA.

Emilia M Swietlik (EM)

Dept of Medicine, University of Cambridge, Cambridge, UK.
Pulmonary Vascular Disease Unit, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.

Tufik R Assad (TR)

Williamson Country Medical Center, Franklin, TN, USA.

Ankit A Desai (AA)

Dept of Medicine, Indiana University, Indianapolis, IN, USA.

Stefan Gräf (S)

Dept of Medicine, University of Cambridge, Cambridge, UK.
NIHR BioResource - Rare Diseases, Cambridge, UK.
Dept of Haematology, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-1315-8873

Lars Harbaum (L)

National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK.

Marc Humbert (M)

Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Paris, France.
AP-HP, Service de Pneumologie, Centre de référence de l'hypertension pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France.
ORCID: 0000-0003-0703-2892

Nicholas W Morrell (NW)

Dept of Medicine, University of Cambridge, Cambridge, UK.
NIHR BioResource - Rare Diseases, Cambridge, UK.

William C Nichols (WC)

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Dept of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Florent Soubrier (F)

Sorbonne Universités, UPMC Univ. Paris 06, Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris, France.
ORCID: 0000-0003-2571-7932

Laura Southgate (L)

Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK.
ORCID: 0000-0002-2090-1450

David-Alexandre Trégouët (DA)

INSERM UMR_S 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.

Richard C Trembath (RC)

Division of Genetics and Molecular Medicine, King's College London, London, UK.

Evan L Brittain (EL)

Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA.
Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA.

Martin R Wilkins (MR)

National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK.

Inga Prokopenko (I)

Dept of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.
Dept of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
These authors contributed equally.

Christopher J Rhodes (CJ)

National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK crhodes@imperial.ac.uk.
These authors contributed equally.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Mendelian randomisation analysis of red cell...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Index érythrocytaires › Mendelian randomisation analysis of red cell...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Mendelian randomisation analysis of red cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mendelian randomisation analysis of red cell...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Hypertension pulmonaire › Mendelian randomisation analysis of red cell...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Hypertension artérielle pulmonaire › Mendelian randomisation analysis of red cell...