Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria.

Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa carbapenem resistance chemical mutagenesis

Journal

mSystems
ISSN: 2379-5077
Titre abrégé: mSystems
Pays: United States
ID NLM: 101680636

Informations de publication

Date de publication:
19 Nov 2019
Historique:
entrez: 21 11 2019
pubmed: 21 11 2019
medline: 21 11 2019
Statut: epublish

Résumé

Carbapenem-resistant Gram-negative bacteria are considered a major threat to global health. Imipenem (IMP) is used as a last line of treatment against these pathogens, but its efficacy is diminished by the emergence of resistance. We applied a whole-genome screen in

Identifiants

pubmed: 31744905
pii: 4/6/e00465-19
doi: 10.1128/mSystems.00465-19
pmc: PMC6867876
pii:
doi:

Types de publication

Journal Article

Langues

eng

Informations de copyright

Copyright © 2019 El Khoury et al.

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Auteurs

Jessica Y El Khoury (JY)

Axe des Maladies Infectieuses et Immunitaires du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, Québec, Canada.

Alexandra Maure (A)

Axe des Maladies Infectieuses et Immunitaires du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, Québec, Canada.

Hélène Gingras (H)

Axe des Maladies Infectieuses et Immunitaires du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, Québec, Canada.

Philippe Leprohon (P)

Axe des Maladies Infectieuses et Immunitaires du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, Québec, Canada.

Marc Ouellette (M)

Axe des Maladies Infectieuses et Immunitaires du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, Québec, Canada Marc.Ouellette@crchul.ulaval.ca.

Classifications MeSH