Breast abnormalities in adolescents receiving antiretroviral therapy.
HIV
adolescent
antiretroviral
breast
gynaecomastia
Journal
Southern African journal of HIV medicine
ISSN: 2078-6751
Titre abrégé: South Afr J HIV Med
Pays: South Africa
ID NLM: 100965417
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
08
2019
accepted:
30
08
2019
entrez:
21
11
2019
pubmed:
21
11
2019
medline:
21
11
2019
Statut:
epublish
Résumé
Antiretrovirals, particularly efavirenz (EFV), have been shown to cause breast abnormalities in adults. Little is known about the prevalence of these adverse effects among adolescents receiving antiretroviral therapy (ART). The aim of this article was to examine the extent of breast abnormalities in adolescents receiving ART and determine any clinical associations. A retrospective record review describing breast conditions in adolescents receiving ART at three facilities in Johannesburg was conducted. Patients aged 10-19 years, who presented from January to December 2014, were included in the study. Analyses were conducted to determine whether EFV was associated with increased breast conditions. Of the 631 patient records reviewed, 37 (6%) had an abnormal breast event documented; with 24/37 (65%) being male patients. Patients with abnormal breast conditions were 1.5 years older than patients with normal breast development ( Of the studied patients, 6% had an abnormal breast condition. The use of EFV and increased age were associated with breast abnormalities in this population. Further research is needed to better understand the implications of this potential side effect.
Sections du résumé
BACKGROUND
BACKGROUND
Antiretrovirals, particularly efavirenz (EFV), have been shown to cause breast abnormalities in adults. Little is known about the prevalence of these adverse effects among adolescents receiving antiretroviral therapy (ART).
OBJECTIVES
OBJECTIVE
The aim of this article was to examine the extent of breast abnormalities in adolescents receiving ART and determine any clinical associations.
METHODS
METHODS
A retrospective record review describing breast conditions in adolescents receiving ART at three facilities in Johannesburg was conducted. Patients aged 10-19 years, who presented from January to December 2014, were included in the study. Analyses were conducted to determine whether EFV was associated with increased breast conditions.
RESULTS
RESULTS
Of the 631 patient records reviewed, 37 (6%) had an abnormal breast event documented; with 24/37 (65%) being male patients. Patients with abnormal breast conditions were 1.5 years older than patients with normal breast development (
CONCLUSION
CONCLUSIONS
Of the studied patients, 6% had an abnormal breast condition. The use of EFV and increased age were associated with breast abnormalities in this population. Further research is needed to better understand the implications of this potential side effect.
Identifiants
pubmed: 31745435
doi: 10.4102/sajhivmed.v20i1.1017
pii: HIVMED-20-1017
pmc: PMC6852609
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1017Informations de copyright
© 2019. The Authors.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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