Light at the end of the tunnel?
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
06
09
2019
revised:
25
09
2019
accepted:
31
10
2019
pubmed:
21
11
2019
medline:
19
6
2020
entrez:
21
11
2019
Statut:
ppublish
Résumé
Discussion on how the modulation of Rev-Erb-alpha and the circadian CLOCK proteins remain an interesting but elusive target for modulation of acute inflammatory response in critical illness.
Identifiants
pubmed: 31746474
doi: 10.1002/JLB.3CE1019-252R
doi:
Substances chimiques
Nuclear Receptor Subfamily 1, Group D, Member 1
0
Types de publication
Editorial
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-8Commentaires et corrections
Type : CommentOn
Informations de copyright
©2019 Society for Leukocyte Biology.
Références
Griepentrog JE, Zhang X, Lewis AJ, et al. Frontline science: rev-Erbα links blue light with enhanced bacterial clearance and improved survival in murine Klebsiella pneumoniae pneumonia. J Leukoc Biol. 2020;107:11-25.
Guidelines for the Management of Adults with Hospital-acquired, Ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388-416.
CRE-carbapenam resistant enetrobacteriacea. CDC mortality and morbidity. 2016; https://www.cdc.gov/hai/organisms/cre/cre-patientgeneral.html.
Yuan D, Collage RD, Huang H, et al. Blue light reduces organ injury from ischemia and reperfusion. Proc Natl Acad Sci U S A. 2016;113:5239-5244.
Solt LA, Wang Y, Banerjee S, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012;485:62-68.
Duez H, Staels B. Rev-erb-alpha: an integrator of circadian rhythms and metabolism. J Appl Physiol. 1985;107:1972-1980.
Raspe E, Duez H, Mansen A, et al. Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription. J Lipid Res. 2002;43:2172-2179.
Reinking J, Lam MM, Pardee K, et al. The Drosophila nuclear receptor e75 contains heme and is gas responsive. Cell. 2005;122:195-207.
Kojetin DJ, Burris TP. REV-ERB and ROR nuclear receptors as drug targets. Nat Rev Drug Discov. 2014;13:197-216.
Fontaine C, Rigamonti E, Pourcet B, et al. The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages. Mol Endocrinol. 2008;22:1797-1811.