Inhibition of the stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease.
Animals
Bleomycin
/ pharmacology
Cell Count
/ methods
Cells, Cultured
Coculture Techniques
/ methods
Female
Fibroblasts
/ drug effects
Fibrosis
/ drug therapy
Humans
Idiopathic Pulmonary Fibrosis
/ drug therapy
Lung
/ drug effects
Mast Cells
/ drug effects
Mice
Mice, Inbred C57BL
Protein Isoforms
/ metabolism
Signal Transduction
/ drug effects
Stem Cell Factor
/ metabolism
Up-Regulation
/ drug effects
cytokines
fibrosis
mast cells
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
pubmed:
21
11
2019
medline:
6
5
2020
entrez:
21
11
2019
Statut:
ppublish
Résumé
Stem cell factor (SCF) and its receptor c-kit have been implicated in inflammation, tissue remodeling, and fibrosis. Ingenuity Integrated Pathway Analysis of gene expression array data sets showed an upregulation of SCF transcripts in idiopathic pulmonary fibrosis (IPF) lung biopsies compared with tissue from nonfibrotic lungs that are further increased in rapid progressive disease. SCF248, a cleavable isoform of SCF, was abundantly and preferentially expressed in human lung fibroblasts and fibrotic mouse lungs relative to the SCF220 isoform. In fibroblast-mast cell coculture studies, blockade of SCF248 using a novel isoform-specific anti-SCF248 monoclonal antibody (anti-SCF248), attenuated the expression of
Identifiants
pubmed: 31747308
doi: 10.1152/ajplung.00114.2019
pmc: PMC6985874
doi:
Substances chimiques
Protein Isoforms
0
Stem Cell Factor
0
Bleomycin
11056-06-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
L200-L211Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL123899
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL144481
Pays : United States
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