Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere.
brain networks
fMRI
functional connectivity
hemispherectomy
plasticity
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
19 11 2019
19 11 2019
Historique:
received:
08
02
2019
revised:
26
07
2019
accepted:
15
10
2019
entrez:
21
11
2019
pubmed:
21
11
2019
medline:
22
9
2020
Statut:
ppublish
Résumé
A reliable set of functional brain networks is found in healthy people and thought to underlie our cognition, emotion, and behavior. Here, we investigated these networks by quantifying intrinsic functional connectivity in six individuals who had undergone surgical removal of one hemisphere. Hemispherectomy subjects and healthy controls were scanned with identical parameters on the same scanner and compared to a large normative sample (n = 1,482). Surprisingly, hemispherectomy subjects and controls all showed strong and equivalent intrahemispheric connectivity between brain regions typically assigned to the same functional network. Connectivity between parts of different networks, however, was markedly increased for almost all hemispherectomy participants and across all networks. These results support the hypothesis of a shared set of functional networks that underlie cognition and suggest that between-network interactions may characterize functional reorganization in hemispherectomy.
Identifiants
pubmed: 31747608
pii: S2211-1247(19)31381-6
doi: 10.1016/j.celrep.2019.10.067
pmc: PMC6914265
mid: NIHMS1544231
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2398-2407.e4Subventions
Organisme : NIMH NIH HHS
ID : P50 MH094258
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS070963
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS086625
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB018907
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG016495
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR019307
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS052585
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105820
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB023281
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG008122
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB019956
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG064027
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH117023
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS072652
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023043
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB006758
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015896
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS083534
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023401
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.