Glutaminolysis and Glycolysis Are Essential for Optimal Replication of Marek's Disease Virus.

Alphaherpesvirinae / metabolism Animals Chick Embryo Chickens / virology Glucose / metabolism Glutamine / metabolism Glycolysis / physiology Herpesvirus 2, Gallid / metabolism Mardivirus / metabolism Marek Disease / metabolism Viral Proteins / metabolism Virus Replication / physiology
Marek’s disease virus glucose glutamine virus replication

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
31 01 2020
Historique:
received: 01 10 2019
accepted: 08 11 2019
pubmed: 22 11 2019
medline: 22 8 2020
entrez: 22 11 2019
Statut: epublish

Résumé

Viruses may hijack glycolysis, glutaminolysis, or fatty acid β-oxidation of host cells to provide the energy and macromolecules required for efficient viral replication. Marek's disease virus (MDV) causes a deadly lymphoproliferative disease in chickens and modulates metabolism of host cells. Metabolic analysis of MDV-infected chicken embryonic fibroblasts (CEFs) identified elevated levels of metabolites involved in glutamine catabolism, such as glutamic acid, alanine, glycine, pyrimidine, and creatine. In addition, our results demonstrate that glutamine uptake is elevated by MDV-infected cells

Identifiants

DOI: 10.1128/JVI.01680-19 PMID: 31748393 PMC: PMC6997755
pubmed: 31748393
pii: JVI.01680-19
doi: 10.1128/JVI.01680-19
pmc: PMC6997755
pii:
doi:

Substances chimiques

Viral Proteins 0
Glutamine 0RH81L854J
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007031
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N002598/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007032
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007030
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Boodhoo et al.

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Auteurs

Nitish Boodhoo (N)

The Pirbright Institute, Woking, United Kingdom.
Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.

Nitin Kamble (N)

The Pirbright Institute, Woking, United Kingdom.

Shayan Sharif (S)

Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.

Shahriar Behboudi (S)

The Pirbright Institute, Woking, United Kingdom shahriar.behboudi@pirbright.ac.uk.
Faculty of Health and Medical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, Surrey, United Kingdom.
ORCID: 0000-0001-6455-4086

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Classifications MeSH

questionsmedicales.fr › Virus › Virus à ADN › Herpesviridae › Alphaherpesvirinae › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Eucaryotes › Animaux › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Embryon de poulet › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Oiseaux › Poulets › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Glutamine › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Virus › Virus à ADN › Herpesviridae › Alphaherpesvirinae › Mardivirus › Herpèsvirus aviaire de type 2 › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Virus › Virus à ADN › Herpesviridae › Alphaherpesvirinae › Mardivirus › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Maladies de l'animal › Maladies des oiseaux › Maladie de Marek › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Glutaminolysis and Glycolysis Are Essential...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Glutaminolysis and Glycolysis Are Essential...