In vitro efficacy of ampelopsin against Echinococcus granulosus and Echinococcus multilocularis.
ampelopsin
echinococcosis
efficacy
toxicity
Journal
The Journal of veterinary medical science
ISSN: 1347-7439
Titre abrégé: J Vet Med Sci
Pays: Japan
ID NLM: 9105360
Informations de publication
Date de publication:
26 Dec 2019
26 Dec 2019
Historique:
pubmed:
22
11
2019
medline:
6
5
2020
entrez:
22
11
2019
Statut:
ppublish
Résumé
The metacestode stage of Echinococcus granulosus and Echinococcus multilocularis cause cystic echinococcosis and alveolar echinococcosis, respectively, which result in severe medical and veterinary problems. In this study, as an exploration of novel treatment agents against echinococcosis, we demonstrated that ampelopsin (AMP), which is extracted from Ampelopsis grossedentata and has been clinically used for treatments of various types of diseases including cancers for a long time, exhibited profound in vitro effect against E. granulosus protoscoleces and E. multilocularis metacestodes. Furthermore, in vitro cytotoxicity assay also demonstrated that AMP at the effective dose against E. granulosus protoscoleces and E. multilocularis metacestodes did not show significant toxicity to human hepatocytes. These results suggest that AMP has the potential as an alternative agent against echinococcosis.
Identifiants
pubmed: 31748438
doi: 10.1292/jvms.19-0347
pmc: PMC6943307
doi:
Substances chimiques
Anticestodal Agents
0
Flavonoids
0
ampelopsin
27200-12-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1853-1858Références
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