Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Journal
Nature reviews. Drug discovery
ISSN: 1474-1784
Titre abrégé: Nat Rev Drug Discov
Pays: England
ID NLM: 101124171
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
accepted:
26
09
2019
pubmed:
22
11
2019
medline:
14
4
2020
entrez:
22
11
2019
Statut:
ppublish
Résumé
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for the detection of human DILI thus remain inadequate. A systematic and concerted research effort is required to address the deficiencies in current models and to present a defined approach towards the development of new or adapted model systems for DILI prediction. This Perspective defines the current status of available models and the mechanistic understanding of DILI, and proposes our vision of a roadmap for the development of predictive preclinical models of human DILI.
Identifiants
pubmed: 31748707
doi: 10.1038/s41573-019-0048-x
pii: 10.1038/s41573-019-0048-x
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-148Subventions
Organisme : Medical Research Council
ID : MR/L006758/1
Pays : United Kingdom
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