Diagnostic utility of small fiber analysis in skin biopsies from children with chronic pain.
epidermal nerve fiber density
neuropathic pain
skin biopsy
small fiber
small fiber neuropathy
sudomotor neurite density
sweat gland innervation
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
12
12
2018
revised:
13
11
2019
accepted:
16
11
2019
pubmed:
22
11
2019
medline:
14
4
2020
entrez:
22
11
2019
Statut:
ppublish
Résumé
Small fiber neuropathies (SFN) are associated with a reduction in quality of life. In adults, epidermal nerve fiber density (END) analysis is recommended for the diagnosis of SFN. In children, END assessment is not often performed. We analyzed small nerve fiber innervation to elucidate the potential diagnostic role of skin biopsies in young patients with pain. Epidermal nerve fiber density and sudomotor neurite density (SND) were assessed in skin biopsies from 26 patients aged 7 to 20 years (15 female patients) with unexplained chronic pain. The results were compared with clinical data. Epidermal nerve fiber density was abnormal in 50% and borderline in 35% of patients. An underlying medical condition was found in 42% of patients, including metabolic, autoimmune, and genetic disorders. Reduction of epidermal nerve fibers can be associated with treatable conditions. Therefore, the analysis of END in children with pain may help to uncover a possible cause and guide potential treatment options.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-181Informations de copyright
© 2019 The Authors. Muscle & Nerve published by Wiley Periodicals, Inc.
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