Exosomes and Female Infertility.
Exosomes
drug delivery
endometrial receptivity
female infertility
microRNAs
oocyte.
Journal
Current drug metabolism
ISSN: 1875-5453
Titre abrégé: Curr Drug Metab
Pays: Netherlands
ID NLM: 100960533
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
04
2019
revised:
28
07
2019
accepted:
04
09
2019
pubmed:
22
11
2019
medline:
30
4
2020
entrez:
22
11
2019
Statut:
ppublish
Résumé
Exosomes are small Extracellular Vesicles (EVs) (40-100 nm) secreted by living cells and mediate the transmission of information between cells. The number and contents of exosomes are associated with diseases such as inflammatory diseases, cancer, metabolic diseases and what we are focusing in this passage-female infertility. This review focused on the role of exosomes in oocyte development, declined ovarian function, PCOS, uterine diseases, endometrial receptivity and fallopian tube dysfunction in the female. We conducted an extensive search for research articles involving relationships between exosomes and female infertility on the bibliographic database. It has been reported that exosomes can act as a potential therapeutic device to carry cargoes to treat female infertility. However, the pathophysiological mechanisms of exosomes in female infertility have not been entirely elucidated. Further researches are needed to explore the etiology and provide evidence for potential clinical treatment. This review systematically summarized the role exosomes play in female infertility and its potential as drug delivery.
Sections du résumé
BACKGROUND
BACKGROUND
Exosomes are small Extracellular Vesicles (EVs) (40-100 nm) secreted by living cells and mediate the transmission of information between cells. The number and contents of exosomes are associated with diseases such as inflammatory diseases, cancer, metabolic diseases and what we are focusing in this passage-female infertility.
OBJECTIVE
OBJECTIVE
This review focused on the role of exosomes in oocyte development, declined ovarian function, PCOS, uterine diseases, endometrial receptivity and fallopian tube dysfunction in the female.
METHODS
METHODS
We conducted an extensive search for research articles involving relationships between exosomes and female infertility on the bibliographic database.
RESULTS
RESULTS
It has been reported that exosomes can act as a potential therapeutic device to carry cargoes to treat female infertility. However, the pathophysiological mechanisms of exosomes in female infertility have not been entirely elucidated. Further researches are needed to explore the etiology and provide evidence for potential clinical treatment.
CONCLUSIONS
CONCLUSIONS
This review systematically summarized the role exosomes play in female infertility and its potential as drug delivery.
Identifiants
pubmed: 31749422
pii: CDM-EPUB-101480
doi: 10.2174/1389200220666191015155910
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
773-780Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.