Effect of N-acetylcysteine on intimal hyperplasia and endothelial proliferation in rabbit carotid artery anastomosis.
N-acetylcysteine
carotid artery
endothelial proliferation
intimal hyperplasia
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
19
06
2018
accepted:
07
08
2018
entrez:
22
11
2019
pubmed:
22
11
2019
medline:
22
11
2019
Statut:
ppublish
Résumé
Neointimal hyperplasia due to smooth muscle cell migration and proliferation, as well as extracellular matrix accumulation, plays an important role in stenosis and restenosis that develop after reconstructive vascular interventions. Various agents are being tested to reduce neointimal hyperplasia and to prevent lumen stenosis. In the present study, the effect of N-acetylcysteine (NAC) on intimal hyperplasia and endothelial hyperplasia after carotid anastomosis was investigated in a rabbit model. In the course of the study, rabbits were divided into two groups. The control group ( Compared with the control group, the reduction in the lumen area and diameter after anastomosis was significantly recovered in the NAC group ( We believe that vascular anastomosis and post-intervention NAC administration will prolong vascular patency by reducing intimal hyperplasia and providing vascular remodeling.
Identifiants
pubmed: 31749887
doi: 10.5114/aoms.2018.77769
pii: 33533
pmc: PMC6855163
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1576-1581Informations de copyright
Copyright: © 2018 Termedia & Banach.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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