A multidisciplinary approach to dosing nusinersen for spinal muscular atrophy.


Journal

Neurology. Clinical practice
ISSN: 2163-0402
Titre abrégé: Neurol Clin Pract
Pays: United States
ID NLM: 101577149

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 21 03 2019
accepted: 21 05 2019
entrez: 22 11 2019
pubmed: 22 11 2019
medline: 22 11 2019
Statut: ppublish

Résumé

In December 2016, nusinersen gained FDA approval as the first pharmacologic treatment for spinal muscular atrophy (SMA), a disorder of motor neurons and the leading genetic cause of infant mortality. Nusinersen's intrathecal delivery requirement, strict dosage protocol, and accelerated FDA approval presented a challenge to health care centers hoping to implement treatment of patients with SMA. Scheduling logistics, combined with the specific ventilatory, anesthetic, and spinal access needs of this patient population, requires extensive coordination of care. This complexity, in addition to the high cost of treatment, may lead to overburdening of an institution's dosing resources, causing delays in treatment initiation and limiting patients' access to therapy and may result in barriers to coverage. We initiated a comprehensive stepwise protocol to maximize patient inclusion, as well as safety and efficiency outcome measures. This retrospective cohort study reviews the dosing process. As a result of immense collaborative efforts involving care coordination of patients and families, in addition to health providers in the divisions of neurology, anesthesiology, pulmonology, orthopedics, interventional radiology, physical therapy, and neurosurgery, we have successfully dosed 62 SMA patients. Throughout this process, we have improved anesthetic techniques, as well as minimized procedural complications and missed scheduled doses. We present here recommendations for safe and effective implementation of nusinersen utilizing a multidisciplinary approach, based on our 1 and a half year experience at a tertiary care children's hospital.

Sections du résumé

BACKGROUND BACKGROUND
In December 2016, nusinersen gained FDA approval as the first pharmacologic treatment for spinal muscular atrophy (SMA), a disorder of motor neurons and the leading genetic cause of infant mortality. Nusinersen's intrathecal delivery requirement, strict dosage protocol, and accelerated FDA approval presented a challenge to health care centers hoping to implement treatment of patients with SMA. Scheduling logistics, combined with the specific ventilatory, anesthetic, and spinal access needs of this patient population, requires extensive coordination of care. This complexity, in addition to the high cost of treatment, may lead to overburdening of an institution's dosing resources, causing delays in treatment initiation and limiting patients' access to therapy and may result in barriers to coverage.
METHODS METHODS
We initiated a comprehensive stepwise protocol to maximize patient inclusion, as well as safety and efficiency outcome measures. This retrospective cohort study reviews the dosing process.
RESULTS RESULTS
As a result of immense collaborative efforts involving care coordination of patients and families, in addition to health providers in the divisions of neurology, anesthesiology, pulmonology, orthopedics, interventional radiology, physical therapy, and neurosurgery, we have successfully dosed 62 SMA patients. Throughout this process, we have improved anesthetic techniques, as well as minimized procedural complications and missed scheduled doses.
CONCLUSION CONCLUSIONS
We present here recommendations for safe and effective implementation of nusinersen utilizing a multidisciplinary approach, based on our 1 and a half year experience at a tertiary care children's hospital.

Identifiants

pubmed: 31750028
doi: 10.1212/CPJ.0000000000000718
pii: NEURCLINPRACT2019039164
pmc: PMC6814423
doi:

Types de publication

Journal Article

Langues

eng

Pagination

424-432

Informations de copyright

© 2019 American Academy of Neurology.

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Auteurs

Carla D Zingariello (CD)

Division of Neurology (CDZ), Department of Pediatrics, University of Florida, Gainesville; Department of Neurology (CDZ, JB, SWY, EAK), University of Pennsylvania; Division of Neurology (CDZ, JB, SWY, EAK), Children's Hospital of Philadelphia; and Department of Anesthesiology (EB, AAH, SD), Department of Physical Therapy (AMG), and Department of Pulmonology (OM), Children's Hospital of Philadelphia, PA.

John Brandsema (J)

Division of Neurology (CDZ), Department of Pediatrics, University of Florida, Gainesville; Department of Neurology (CDZ, JB, SWY, EAK), University of Pennsylvania; Division of Neurology (CDZ, JB, SWY, EAK), Children's Hospital of Philadelphia; and Department of Anesthesiology (EB, AAH, SD), Department of Physical Therapy (AMG), and Department of Pulmonology (OM), Children's Hospital of Philadelphia, PA.

Elizabeth Drum (E)

Division of Neurology (CDZ), Department of Pediatrics, University of Florida, Gainesville; Department of Neurology (CDZ, JB, SWY, EAK), University of Pennsylvania; Division of Neurology (CDZ, JB, SWY, EAK), Children's Hospital of Philadelphia; and Department of Anesthesiology (EB, AAH, SD), Department of Physical Therapy (AMG), and Department of Pulmonology (OM), Children's Hospital of Philadelphia, PA.

Alicia A Henderson (AA)

Division of Neurology (CDZ), Department of Pediatrics, University of Florida, Gainesville; Department of Neurology (CDZ, JB, SWY, EAK), University of Pennsylvania; Division of Neurology (CDZ, JB, SWY, EAK), Children's Hospital of Philadelphia; and Department of Anesthesiology (EB, AAH, SD), Department of Physical Therapy (AMG), and Department of Pulmonology (OM), Children's Hospital of Philadelphia, PA.

Scott Dubow (S)

Division of Neurology (CDZ), Department of Pediatrics, University of Florida, Gainesville; Department of Neurology (CDZ, JB, SWY, EAK), University of Pennsylvania; Division of Neurology (CDZ, JB, SWY, EAK), Children's Hospital of Philadelphia; and Department of Anesthesiology (EB, AAH, SD), Department of Physical Therapy (AMG), and Department of Pulmonology (OM), Children's Hospital of Philadelphia, PA.

Allan M Glanzman (AM)

Division of Neurology (CDZ), Department of Pediatrics, University of Florida, Gainesville; Department of Neurology (CDZ, JB, SWY, EAK), University of Pennsylvania; Division of Neurology (CDZ, JB, SWY, EAK), Children's Hospital of Philadelphia; and Department of Anesthesiology (EB, AAH, SD), Department of Physical Therapy (AMG), and Department of Pulmonology (OM), Children's Hospital of Philadelphia, PA.

Oscar Mayer (O)

Division of Neurology (CDZ), Department of Pediatrics, University of Florida, Gainesville; Department of Neurology (CDZ, JB, SWY, EAK), University of Pennsylvania; Division of Neurology (CDZ, JB, SWY, EAK), Children's Hospital of Philadelphia; and Department of Anesthesiology (EB, AAH, SD), Department of Physical Therapy (AMG), and Department of Pulmonology (OM), Children's Hospital of Philadelphia, PA.

Sabrina W Yum (SW)

Division of Neurology (CDZ), Department of Pediatrics, University of Florida, Gainesville; Department of Neurology (CDZ, JB, SWY, EAK), University of Pennsylvania; Division of Neurology (CDZ, JB, SWY, EAK), Children's Hospital of Philadelphia; and Department of Anesthesiology (EB, AAH, SD), Department of Physical Therapy (AMG), and Department of Pulmonology (OM), Children's Hospital of Philadelphia, PA.

Elizabeth A Kichula (EA)

Division of Neurology (CDZ), Department of Pediatrics, University of Florida, Gainesville; Department of Neurology (CDZ, JB, SWY, EAK), University of Pennsylvania; Division of Neurology (CDZ, JB, SWY, EAK), Children's Hospital of Philadelphia; and Department of Anesthesiology (EB, AAH, SD), Department of Physical Therapy (AMG), and Department of Pulmonology (OM), Children's Hospital of Philadelphia, PA.

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