Protective Effects of Silymarin Against Age-Related Hearing Loss in an Aging Rat Model.
Age-related hearing loss
Silymarin
d-Galactose
Journal
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
ISSN: 2231-3796
Titre abrégé: Indian J Otolaryngol Head Neck Surg
Pays: India
ID NLM: 9422551
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
15
08
2017
accepted:
07
03
2018
entrez:
22
11
2019
pubmed:
22
11
2019
medline:
22
11
2019
Statut:
ppublish
Résumé
Age-related hearing loss (ARHL) is one of the most common chronic degenerative disorders. Several studies have indicated that supplementation with some antioxidants can slow down the progression of ARHL. Despite several lines of evidence about the potent antioxidant and anti-aging effects of silymarin, its protective effect against ARHL has not evaluated yet. The aim of the current study was to investigate the effects of silymarin in prevention of ARHL in a d-Galactose-induced aging rat model for the first time. 45 male wistar rats aged 3-month old were divided into 5 groups: group 1, 2 and 3 received 500 mg/kg/day d-Gal plus 100, 200 and 300 mg/kg/day silymarin respectively for 8 weeks, placebo group received 500 mg/kg/day d-Gal plus propylene glycol as placebo, and control group received normal saline during this period of time. Auditory brainstem responses were measured at several frequencies (4, 6, 8, 12 and 16 kHz) before and after the intervention. Placebo group and group 3 showed significant ABR threshold increase across frequencies of 4, 6, 16 kHz compared with the other groups (
Identifiants
pubmed: 31750160
doi: 10.1007/s12070-018-1294-7
pii: 1294
pmc: PMC6841879
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1248-1257Informations de copyright
© Association of Otolaryngologists of India 2018.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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