Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models.
STEMI
acute myocardial infarction
animal models
anti-arrhythmia agents
ischemia
sudden cardiac death
ventricular arrhythmia
ventricular fibrillation
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
05
2019
accepted:
18
10
2019
entrez:
22
11
2019
pubmed:
22
11
2019
medline:
22
11
2019
Statut:
epublish
Résumé
Ventricular arrhythmia and subsequent sudden cardiac death (SCD) due to acute myocardial infarction (AMI) is one of the most frequent causes of death in humans. Lethal ventricular arrhythmias like ventricular fibrillation (VF) prior to hospitalization have been reported to occur in more than 10% of all AMI cases and survival in these patients is poor. Identification of risk factors and mechanisms for VF following AMI as well as implementing new risk stratification models and therapeutic approaches is therefore an important step to reduce mortality in people with high cardiovascular risk. Studying spontaneous VF following AMI in humans is challenging as it often occurs unexpectedly in a low risk subgroup. Large animal models of AMI can help to bridge this knowledge gap and are utilized to investigate occurrence of arrhythmias, involved mechanisms and therapeutic options. Comparable anatomy and physiology allow for this translational approach. Through experimental focus, using state-of-the-art technologies, including refined electrical mapping equipment and novel pharmacological investigations, valuable insights into arrhythmia mechanisms and possible interventions for arrhythmia-induced SCD during the early phase of AMI are now beginning to emerge. This review describes large experimental animal models of AMI with focus on first AMI-associated ventricular arrhythmias. In this context, epidemiology of first AMI, arrhythmogenic mechanisms and various potential therapeutic pharmacological targets will be discussed.
Identifiants
pubmed: 31750317
doi: 10.3389/fcvm.2019.00158
pmc: PMC6848060
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
158Informations de copyright
Copyright © 2019 Sattler, Skibsbye, Linz, Lubberding, Tfelt-Hansen and Jespersen.
Références
Heart Rhythm. 2013 Oct;10(10):1525-30
pubmed: 23851058
Circulation. 1998 Nov 24;98(21):2334-51
pubmed: 9826323
Cardiovasc Drugs Ther. 2012 Jun;26(3):195-204
pubmed: 22450779
Physiol Rev. 1999 Jul;79(3):917-1017
pubmed: 10390520
Circ Res. 2014 Mar 14;114(6):1004-21
pubmed: 24625726
J Mol Cell Cardiol. 2012 Apr;52(4):897-904
pubmed: 21959171
N Engl J Med. 2016 May 5;374(18):1711-22
pubmed: 27043165
J Electrocardiol. 2001;34 Suppl:17-26
pubmed: 11781932
Circulation. 2016 Dec 20;134(25):2074-2083
pubmed: 27793995
Int J Cardiol. 2019 Jul 15;287:181-188
pubmed: 30497894
J Am Assoc Lab Anim Sci. 2011 Jan;50(1):73-8
pubmed: 21333167
J Cardiovasc Electrophysiol. 2003 May;14(5):510-20
pubmed: 12776869
J Cell Mol Med. 2015 Nov;19(11):2655-63
pubmed: 26282710
Cardiovasc Res. 1992 Jun;26(6):571-9
pubmed: 1451136
Basic Res Cardiol. 1993 Sep-Oct;88(5):443-55
pubmed: 8117250
Lab Anim Sci. 1993 Jun;43(3):210-6
pubmed: 8355479
Circulation. 1999 Nov 9;100(19):2025-34
pubmed: 10556230
J Anat. 1998 Jul;193 ( Pt 1):105-19
pubmed: 9758141
Eur Heart J. 2014 Jan;35(2):116-22
pubmed: 24258072
J Am Heart Assoc. 2014 Feb 28;3(1):e000495
pubmed: 24584738
J Mol Cell Cardiol. 2010 Jan;48(1):71-5
pubmed: 19607836
Circ Res. 2015 Jun 5;116(12):1937-55
pubmed: 26044249
Am J Hypertens. 2014 Oct;27(10):1293-300
pubmed: 24622919
Circulation. 1988 Jan;77(1):200-8
pubmed: 2446801
Am J Cardiol. 2015 Sep 1;116(5):678-85
pubmed: 26150175
Am J Physiol. 1983 Jul;245(1):H82-9
pubmed: 6869567
J Am Coll Cardiol. 2002 Jan 2;39(1):166-76
pubmed: 11755303
Drugs. 2007;67 Suppl 2:15-24
pubmed: 17999560
Circulation. 1997 Nov 4;96(9):3079-86
pubmed: 9386178
Circulation. 1979 Aug;60(2):397-403
pubmed: 445757
JAMA. 2013 Oct 2;310(13):1377-84
pubmed: 24084923
Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H433-9
pubmed: 17369457
J Mol Cell Cardiol. 2006 Feb;40(2):258-66
pubmed: 16427077
Circulation. 2013 Jan 29;127(4):e362-425
pubmed: 23247304
Circulation. 2012 Jan 31;125(4):620-37
pubmed: 22294707
J Am Coll Cardiol. 1997 Nov 15;30(6):1500-5
pubmed: 9362408
Chaos. 1998 Mar;8(1):149-156
pubmed: 12779718
J Cardiovasc Electrophysiol. 2000 Mar;11(3):290-304
pubmed: 10749352
Eur Heart J. 2006 Sep;27(17):2099-140
pubmed: 16923744
Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H10-6
pubmed: 12623782
Eur Heart J. 1992 Sep;13(9):1282-9
pubmed: 1396841
Atherosclerosis. 2002 May;162(1):211-6
pubmed: 11947916
Circulation. 2006 Sep 12;114(11):1140-5
pubmed: 16940195
J Surg Res. 2013 Nov;185(1):152-8
pubmed: 23773712
Prog Biophys Mol Biol. 2014 Aug;115(2-3):252-60
pubmed: 24972083
Lancet. 1996 Jul 6;348(9019):7-12
pubmed: 8691967
Circulation. 2006 Oct 3;114(14):1462-7
pubmed: 17000909
Eur Heart J. 2013 Sep;34(34):2674-82
pubmed: 23739241
N Engl J Med. 2001 Nov 15;345(20):1473-82
pubmed: 11794197
J Am Heart Assoc. 2015 Jan 05;4(1):e001399
pubmed: 25559012
Cardiovasc Drugs Ther. 1994 Oct;8(5):749-56
pubmed: 7873472
J Am Coll Cardiol. 2014 Jan 28;63(3):215-24
pubmed: 24140663
Cardiovasc Res. 1981 Feb;15(2):80-5
pubmed: 7260980
Heart Rhythm. 2010 Jan;7(1):65-71
pubmed: 19939739
Am Heart J. 1975 Jun;89(6):731-41
pubmed: 1130266
Resuscitation. 2013 Mar;84(3):384-90
pubmed: 22940600
Diabetologia. 2008 Apr;51(4):675-85
pubmed: 18251006
Prog Biophys Mol Biol. 2003 May-Jul;82(1-3):187-95
pubmed: 12732278
Circulation. 1999 Aug 31;100(9):944-50
pubmed: 10468525
Cardiology. 2011;118(3):147-52
pubmed: 21606647
Physiol Rev. 1989 Oct;69(4):1049-169
pubmed: 2678165
Am J Cardiol. 1964 Mar;13:349-54
pubmed: 14128645
Can J Cardiol. 1985 Jan;1(1):56-65
pubmed: 3850764
Cardiovasc Res. 1997 Jul;35(1):13-29
pubmed: 9302343
Ann Intern Med. 2002 Feb 5;136(3):181-91
pubmed: 11827493
Circulation. 2009 Nov 3;120(18):1822-36
pubmed: 19884481
Biochem Pharmacol. 1976 Jan 15;25(2):131-4
pubmed: 1259774
Circulation. 1995 Jan 15;91(2):471-5
pubmed: 7805252
Cardiol Young. 2016 Mar;26(3):451-8
pubmed: 25872028
Circ Res. 2015 Jun 5;116(12):2005-19
pubmed: 26044253
Cardiovasc Res. 2001 May;50(2):362-72
pubmed: 11334840
Physiol Rev. 2005 Oct;85(4):1205-53
pubmed: 16183911
J Am Coll Cardiol. 2000 Jan;35(1):144-50
pubmed: 10636272
Circulation. 1995 Nov 15;92(10):3051-60
pubmed: 7586276
N Engl J Med. 1991 Mar 21;324(12):781-8
pubmed: 1900101
Heart Rhythm. 2010 Oct;7(10):1374-80
pubmed: 20638933
Biochem Soc Trans. 2015 Jun;43(3):508-12
pubmed: 26009199
Circ Res. 2013 Mar 1;112(5):849-62
pubmed: 23449547
Am J Physiol. 1992 Jun;262(6 Pt 2):H1719-24
pubmed: 1621830
J Cardiovasc Pharmacol. 1994 Jan;23(1):72-8
pubmed: 7511739
Comp Med. 2008 Dec;58(6):568-79
pubmed: 19149414
Naunyn Schmiedebergs Arch Pharmacol. 2000 Feb;361(2):155-60
pubmed: 10685870
Br J Pharmacol Chemother. 1962 Dec;19(3):394-404
pubmed: 19108169
Circ Res. 1999 Oct 29;85(9):777-86
pubmed: 10532945
Front Physiol. 2019 Mar 11;10:200
pubmed: 30914967
J Interv Card Electrophysiol. 2015 Mar;42(2):83-9
pubmed: 25591724
Heart Rhythm. 2008 Jan;5(1):71-8
pubmed: 18180022
J Pharmacol Toxicol Methods. 2011 Mar-Apr;63(2):186-95
pubmed: 20951813
Circulation. 1987 Nov;76(5):1127-34
pubmed: 3664997
Nat Genet. 2010 Aug;42(8):688-691
pubmed: 20622880
J Am Coll Cardiol. 1994 Jan;23(1):253-8
pubmed: 8277089
N Engl J Med. 1971 Jun 10;284(23):1277-81
pubmed: 5576437
Mol Med Rep. 2014 Oct;10(4):2039-44
pubmed: 25051102
Br Heart J. 1992 Nov;68(5):443-8
pubmed: 1467026
Circulation. 2002 Dec 10;106(24):2999-3001
pubmed: 12473541
Circ Arrhythm Electrophysiol. 2014 Apr;7(2):205-11
pubmed: 24604905
Heart Rhythm. 2011 Jun;8(6):892-8
pubmed: 21255678
Cardiovasc Res. 1998 Jul;39(1):165-77
pubmed: 9764198
Eur Heart J. 2007 Oct;28(20):2525-38
pubmed: 17951287
Br J Anaesth. 2016 Jun;116(6):784-9
pubmed: 27199311
J Electrocardiol. 2000 Apr;33(2):159-70
pubmed: 10819409
Crit Care Med. 2011 Jan;39(1):78-83
pubmed: 20959785
Circ Res. 1993 Mar;72(3):671-87
pubmed: 8431990
Lancet. 2005 Nov 5;366(9497):1622-32
pubmed: 16271643
Am Heart J. 1982 Sep;104(3):537-44
pubmed: 7113893
Proc Soc Exp Biol Med. 1978 Jun;158(2):135-40
pubmed: 97672
Circ Res. 1991 May;68(5):1471-81
pubmed: 2019002
J Cardiovasc Magn Reson. 2009 Sep 23;11:38
pubmed: 19775428
Resuscitation. 2011 Aug;82(8):1092-9
pubmed: 21561702
Pharmacol Res. 2015 May-Jun;95-96:92-101
pubmed: 25836920
Circ Res. 1990 Mar;66(3):672-95
pubmed: 2306802
Circulation. 1950 Jan;1(1):10-27, pl
pubmed: 15401193
J Cardiovasc Pharmacol. 2008 Dec;52(6):548-54
pubmed: 19034029
Eur J Pharmacol. 1996 Dec 19;317(2-3):309-16
pubmed: 8997615
Circulation. 2006 Aug 8;114(6):536-42
pubmed: 16880326
Cardiovasc Res. 2014 Jul 1;103(1):72-80
pubmed: 24654232
ANZ J Surg. 2008 Jan-Feb;78(1-2):78-81
pubmed: 18199212
Lab Anim. 2004 Apr;38(2):149-57
pubmed: 15070454
Am J Physiol. 1989 Dec;257(6 Pt 2):H1886-94
pubmed: 2603974
Eur Heart J. 1984 Dec;5(12):960-73
pubmed: 6442888
Int Heart J. 2016 May 25;57(3):327-35
pubmed: 27150000
J Thorac Dis. 2014 Sep;6(9):1271-7
pubmed: 25276369
Prog Biophys Mol Biol. 2016 Jan;120(1-3):199-209
pubmed: 26780507
Circulation. 1950 Jun;1(6):1318-28
pubmed: 15414549
Circulation. 2003 May 6;107(17):2213-20
pubmed: 12707241
Circulation. 1974 Jan;49(1):32-41
pubmed: 4271710
Circulation. 1984 Apr;69(4):790-800
pubmed: 6697463
Curr Pharm Des. 2018;24(3):323-340
pubmed: 29332573
Am J Physiol. 1960 Mar;198:537-42
pubmed: 14399296
Basic Res Cardiol. 2001 Apr;96(2):192-7
pubmed: 11327338
J Anim Sci. 2007 Jan;85(1):84-92
pubmed: 17179543
J Cardiovasc Transl Res. 2019 Aug;12(4):321-330
pubmed: 30617762
J Am Coll Cardiol. 1986 May;7(5):1047-56
pubmed: 3958360
J Geriatr Cardiol. 2016 Sep;13(9):789-797
pubmed: 27899944
Pharmacol Ther. 2007 Feb;113(2):276-95
pubmed: 17070922