Multicenter Validation of the CamGFR Model for Estimated Glomerular Filtration Rate.
Journal
JNCI cancer spectrum
ISSN: 2515-5091
Titre abrégé: JNCI Cancer Spectr
Pays: England
ID NLM: 101721827
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
31
01
2019
revised:
13
07
2019
accepted:
23
08
2019
entrez:
22
11
2019
pubmed:
22
11
2019
medline:
22
11
2019
Statut:
epublish
Résumé
Important oncological management decisions rely on kidney function assessed by serum creatinine-based estimated glomerular filtration rate (eGFR). However, no large-scale multicenter comparisons of methods to determine eGFR in patients with cancer are available. To compare the performance of formulas for eGFR based on routine clinical parameters and serum creatinine not calibrated with isotope dilution mass spectrometry, we studied 3620 patients with cancer and 166 without cancer who had their glomerular filtration rate (GFR) measured with an exogenous nuclear tracer at one of seven clinical centers. The mean measured GFR was 86 mL/min. Accuracy of all models was center dependent, reflecting intercenter variability of isotope dilution mass spectrometry-creatinine measurements. CamGFR was the most accurate model for eGFR (root-mean-squared error 17.3 mL/min) followed by the Chronic Kidney Disease Epidemiology Collaboration model (root-mean-squared error 18.2 mL/min).
Identifiants
pubmed: 31750418
doi: 10.1093/jncics/pkz068
pii: pkz068
pmc: PMC6846361
doi:
Types de publication
Journal Article
Langues
eng
Pagination
pkz068Subventions
Organisme : NCI NIH HHS
ID : P30 CA045508
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press.
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