Enhanced Antipsoriatic Activity of Mycophenolic Acid Against the TNF-α-Induced HaCaT Cell Proliferation by Conjugated Poloxamer Micelles.
antipsoriatic activity
mycophenolic acid
poloxamer
polymer conjugation
polymeric micelles
psoriasis
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
09
07
2019
revised:
11
10
2019
accepted:
12
11
2019
pubmed:
22
11
2019
medline:
22
6
2021
entrez:
22
11
2019
Statut:
ppublish
Résumé
Mycophenolic acid (MPA), an immunosuppressant drug, possesses antimicrobial, anticancer, and antipsoriatic activities. However, the use of MPA in therapeutic applications is limited to its poor oral bioavailability, low aqueous solubility, and undesired gastrointestinal side effects. Polymeric micelles are a drug delivery system that has been used to enhance the water solubility of pharmaceuticals. In this work, poloxamer 407 (P407) and MPA were conjugated via an ester linkage resulting in a P407-MPA conjugate. The P407-MPA conjugate was investigated for micellization, particle size, size distribution, MPA release in phosphate buffer (pH 7.4) and human plasma, and antipsoriatic activity.
Identifiants
pubmed: 31751564
pii: S0022-3549(19)30753-1
doi: 10.1016/j.xphs.2019.11.010
pii:
doi:
Substances chimiques
Drug Carriers
0
Micelles
0
Tumor Necrosis Factor-alpha
0
Poloxamer
106392-12-5
Polyethylene Glycols
3WJQ0SDW1A
Mycophenolic Acid
HU9DX48N0T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1153-1160Informations de copyright
Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.