Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs.

Binding, Competitive Calcium / metabolism Calcium-Binding Proteins / genetics Cardiomyopathy, Dilated / metabolism Dependovirus / metabolism Fluorescence Resonance Energy Transfer HEK293 Cells Humans Induced Pluripotent Stem Cells / metabolism Loss of Function Mutation / genetics Mutation / genetics Myocytes, Cardiac / metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases / antagonists & inhibitors
Calcium transport Cardiomyocyte Dilated cardiomyopathy Gene therapy Phospholamban SERCA

Journal

Journal of molecular and cellular cardiology
ISSN: 1095-8584
Titre abrégé: J Mol Cell Cardiol
Pays: England
ID NLM: 0262322

Informations de publication

Date de publication:
01 2020
Historique:
received: 22 08 2019
revised: 04 11 2019
accepted: 10 11 2019
pubmed: 22 11 2019
medline: 22 1 2021
entrez: 22 11 2019
Statut: ppublish

Résumé

There is increasing momentum toward the development of gene therapy for heart failure (HF) that is defined by impaired calcium (Ca

Identifiants

DOI: 10.1016/j.yjmcc.2019.11.147 PMID: 31751570 PMC: PMC7035975
pubmed: 31751570
pii: S0022-2828(19)30373-6
doi: 10.1016/j.yjmcc.2019.11.147
pmc: PMC7035975
mid: NIHMS1543535
pii:
doi:

Substances chimiques

Calcium-Binding Proteins 0
phospholamban 0
Sarcoplasmic Reticulum Calcium-Transporting ATPases EC 3.6.3.8
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

59-65

Subventions

Organisme : NIA NIH HHS
ID : R37 AG026160
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007612
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144130
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR032961
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG026160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139065
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM027906
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129814
Pays : United States

Informations de copyright

Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

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Auteurs

Daniel R Stroik (DR)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States of America.

Delaine K Ceholski (DK)

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York City, New York 10029, United States of America.

Philip A Bidwell (PA)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States of America; Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, United States of America.

Justyna Mleczko (J)

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York City, New York 10029, United States of America.

Paul F Thanel (PF)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States of America.

Forum Kamdar (F)

Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, United States of America.

Joseph M Autry (JM)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States of America.

Razvan L Cornea (RL)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States of America.

David D Thomas (DD)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States of America. Electronic address: ddt@umn.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Fixation compétitive › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Laminopathies › Cardiomyopathie dilatée › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Virus › Virus à ADN › Parvoviridae › Parvovirinae › Dependovirus › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Transfert d'énergie par résonance de fluorescence › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Viral expression of a SERCA2a-activating PLB...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › P-type ATPases › Calcium-Transporting ATPases › Sarcoplasmic Reticulum Calcium-Transporting ATPases › Viral expression of a SERCA2a-activating PLB...