Circulating concentration of interleukin-37 in Helicobacter pylori-infected patients with peptic ulcer: Its association with IL-37 related gene polymorphisms and bacterial virulence factor CagA.
Adult
Antibodies, Bacterial
/ blood
Antigens, Bacterial
/ immunology
Bacterial Proteins
/ immunology
Female
Gene Frequency
/ genetics
Helicobacter Infections
/ blood
Helicobacter pylori
/ pathogenicity
Humans
Immunoglobulin A
/ blood
Immunoglobulin G
/ blood
Interleukin-1
/ blood
Male
Peptic Ulcer
/ blood
Polymorphism, Single Nucleotide
/ genetics
Gene polymorphisms
Helicobacter pylori
Interleukin-37
Peptic ulcer
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
02
03
2019
revised:
12
11
2019
accepted:
13
11
2019
pubmed:
22
11
2019
medline:
30
6
2021
entrez:
22
11
2019
Statut:
ppublish
Résumé
The immunopathologic responses play a major role in the development of H. pylori (HP)-related gastrointestinal diseases. IL-37 is an anti-inflammatory cytokine with potent suppressive effects on innate and adaptive immune responses. Here, we investigated the IL-37 levels and two single nucleotide polymorphisms (SNPs) including rs3811047 and rs2723176 in IL-37 gene in HP-infected peptic ulcer (PU) patients to identify any relationship. Three groups, including 100 HP-infected PU patients, 100 HP-infected asymptomatic (AS) subjects and 100 non-infected healthy control (NHC) subjects were enrolled to study. Serum IL-37 levels and the genotyping at rs3811047 and rs2723176 were determined using ELISA and SSP-PCR methods, respectively. Significantly higher IL-37 levels were observed in PU patients compared with AS and NHC groups (P < 0.0001). In both PU and AS groups, the CagA
Identifiants
pubmed: 31751903
pii: S1043-4666(19)30357-6
doi: 10.1016/j.cyto.2019.154928
pii:
doi:
Substances chimiques
Antibodies, Bacterial
0
Antigens, Bacterial
0
Bacterial Proteins
0
IL37 protein, human
0
Immunoglobulin A
0
Immunoglobulin G
0
Interleukin-1
0
cagA protein, Helicobacter pylori
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
154928Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.