Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells.
Amino Acid Transport System y+
/ antagonists & inhibitors
Animals
Butyric Acid
/ immunology
Fusion Regulatory Protein 1, Light Chains
/ antagonists & inhibitors
Gene Expression
Homeostasis
Immunity, Innate
Intestine, Small
/ metabolism
Leucine
/ immunology
Mice
Mice, Inbred ICR
Microbiota
Paneth Cells
/ metabolism
Receptors, G-Protein-Coupled
/ antagonists & inhibitors
alpha-Defensins
/ metabolism
Gpr41
Paneth cell
Slc7a8
amino acid
butyric acid
innate immunity
intestinal microbiota
leucine
short-chain fatty acid
α-defensin
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
18 Nov 2019
18 Nov 2019
Historique:
received:
15
08
2019
revised:
04
11
2019
accepted:
13
11
2019
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
26
6
2020
Statut:
epublish
Résumé
The intestine not only plays a role in fundamental processes in digestion and nutrient absorption, but it also has a role in eliminating ingested pathogenic bacteria and viruses. Paneth cells, which reside at the base of small intestinal crypts, secrete α-defensins and contribute to enteric innate immunity through potent microbicidal activities. However, the relationship between food factors and the innate immune functions of Paneth cells remains unknown. Here, we examined whether short-chain fatty acids and amino acids induce α-defensin secretion from Paneth cells in the isolated crypts of small intestine. Butyric acid and leucine elicit α-defensin secretion by Paneth cells, which kills
Identifiants
pubmed: 31752111
pii: nu11112817
doi: 10.3390/nu11112817
pmc: PMC6893607
pii:
doi:
Substances chimiques
Amino Acid Transport System y+
0
Ffar2 protein, mouse
0
Fusion Regulatory Protein 1, Light Chains
0
Gpcr41 protein, mouse
0
Hcar2 protein, mouse
0
Receptors, G-Protein-Coupled
0
SLC7A8 protein, mouse
0
alpha-Defensins
0
Butyric Acid
107-92-6
Leucine
GMW67QNF9C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18K17931, 17K11661, 18H02788
Organisme : Special Research Grant from Tenshi College
ID : 2017
Organisme : Center of Innovation Program from the Japan Science and Technology Agency
ID : JPMJCE1301
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