Current and Future Concepts for the Treatment of Impaired Fracture Healing.
biomaterials
fracture healing
non-union
osteoanabolic molecules
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Nov 2019
19 Nov 2019
Historique:
received:
30
10
2019
revised:
15
11
2019
accepted:
15
11
2019
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
9
4
2020
Statut:
epublish
Résumé
Bone regeneration represents a complex process, of which basic biologic principles have been evolutionarily conserved over a broad range of different species. Bone represents one of few tissues that can heal without forming a fibrous scar and, as such, resembles a unique form of tissue regeneration. Despite a tremendous improvement in surgical techniques in the past decades, impaired bone regeneration including non-unions still affect a significant number of patients with fractures. As impaired bone regeneration is associated with high socio-economic implications, it is an essential clinical need to gain a full understanding of the pathophysiology and identify novel treatment approaches. This review focuses on the clinical implications of impaired bone regeneration, including currently available treatment options. Moreover, recent advances in the understanding of fracture healing are discussed, which have resulted in the identification and development of novel therapeutic approaches for affected patients.
Identifiants
pubmed: 31752267
pii: ijms20225805
doi: 10.3390/ijms20225805
pmc: PMC6888215
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Else Kröner-Fresenius-Stiftung
ID : EKFS 2017_A22
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG KE 2179/2-1
Organisme : Berlin Institute of Health
ID : BIH
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