New murine models of aggressive lymphoma.

Animals B-Lymphocytes Disease Models, Animal Germinal Center Lymphoma, Large B-Cell, Diffuse / drug therapy Mice Mutation
Murine models aggressive lymphoma diffuse large B cell lymphoma

Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
04 2020
Historique:
pubmed: 23 11 2019
medline: 28 4 2021
entrez: 23 11 2019
Statut: ppublish

Résumé

Diffuse large B cell lymphoma (DLBCL) is the most common type of aggressive lymphoma and has traditionally been subdivided into germinal center B cell-like and activated B cell-like DLBCL, using transcriptome profiling. The recent characterization of the genomic landscape of DLBCL revealed the identity of at least five molecularly-defined subclusters of DLBCL. Intriguingly, these different clusters display a different response to frontline, anthracycline-based chemo-immune therapy. Moreover, multiple, potentially actionable genomic aberrations have been identified in these clusters, including

Identifiants

DOI: 10.1080/10428194.2019.1691200 PMID: 31752573
pubmed: 31752573
doi: 10.1080/10428194.2019.1691200
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

788-798

Auteurs

Ruth Flümann (R)

Department I of Internal Medicine, University Hospital of Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Pascal Nieper (P)

Department I of Internal Medicine, University Hospital of Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Hans Christian Reinhardt (HC)

Department I of Internal Medicine, University Hospital of Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Center of Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Center of Molecular Medicine, University of Cologne, Cologne, Germany.

Gero Knittel (G)

Department I of Internal Medicine, University Hospital of Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › New murine models of aggressive lymphoma.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › New murine models of aggressive lymphoma.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › New murine models of aggressive lymphoma.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Centre germinatif › New murine models of aggressive lymphoma.
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome B › Lymphome B diffus à grandes cellules › New murine models of aggressive lymphoma.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › New murine models of aggressive lymphoma.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › New murine models of aggressive lymphoma.