How It Works: The Immunology Underlying Phototherapy.

Humans Immunity, Cellular Keratinocytes / immunology Phototherapy / methods Psoriasis / immunology T-Lymphocytes, Regulatory / immunology
) Apoptosis IL-23/T(H)17 axis Immunosuppression Phototherapy Platelet-activating factor Regulatory T cells (Tregs UV radiation Urocanic acid

Journal

Dermatologic clinics
ISSN: 1558-0520
Titre abrégé: Dermatol Clin
Pays: United States
ID NLM: 8300886

Informations de publication

Date de publication:
Jan 2020
Historique:
entrez: 23 11 2019
pubmed: 23 11 2019
medline: 2 6 2020
Statut: ppublish

Résumé

Phototherapeutic modalities induce apoptosis of keratinocytes and immune cells, impact cytokine production, downregulate the IL-23/Th17 axis, and induce regulatory T cells. As in anti-IL-17 or anti-IL-23 antibody treatment, the dual action of phototherapy on skin and the immune system is likely responsible for sustained resolution of lesions in diseases such as psoriasis. In cutaneous T cell lymphoma, phototherapy may function by causing tumor cell apoptosis and eliminating the neoplastic and inflammatory infiltrate. Further research on phototherapeutic mechanisms will help advance, optimize, and refine dermatologic treatments and may open up novel avenues for treatment strategies in dermatology and beyond.

Identifiants

DOI: 10.1016/j.det.2019.08.004 PMID: 31753191
pubmed: 31753191
pii: S0733-8635(19)30083-X
doi: 10.1016/j.det.2019.08.004
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

37-53

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Zizi Yu (Z)

Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

Peter Wolf (P)

Department of Dermatology, Research Unit for Photodermatology, Medical University of Graz, Auenbruggerplatz 8, Graz A-8036, Austria. Electronic address: peter.wolf@medunigraz.at.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › How It Works: The Immunology Underlying Phototherapy.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › How It Works: The Immunology Underlying Phototherapy.
questionsmedicales.fr › Cellules › Cellules épithéliales › Kératinocytes › How It Works: The Immunology Underlying Phototherapy.
questionsmedicales.fr › Thérapeutique › Photothérapie › How It Works: The Immunology Underlying Phototherapy.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › How It Works: The Immunology Underlying Phototherapy.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › How It Works: The Immunology Underlying Phototherapy.